FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077534140> ?p ?o ?g. }

• W2077534140 endingPage "1485" @default.
• W2077534140 startingPage "1477" @default.
• W2077534140 abstract "Bothropstoxin-I (BthTX-I), the principal myotoxin of Bothrops jararacussu venom, is devoid of phospholipase A(2) (PLA(2)) activity but capable of blocking neuromuscular transmission in mouse nerve-muscle preparations. In this study, the ability of crotoxin antiserum and heparin in preventing the neurotoxic and myotoxic effects of BthTX-I was investigated. Phrenic nerve-diaphragm preparations (PND) stimulated indirectly with supramaximal stimuli (0.2 ms, 0.1 Hz) were incubated with BthTX-I (20 microg/ml) alone or with BthTX-I preincubated with antiserum or heparin for 30 min at 37 degrees C prior to testing. Control preparations were incubated with Tyrode solution, antiserum or heparin alone. BthTX-I (20 microg/ml) produced 50% neuromuscular blockade in the PND preparations in 31+/-4min, with complete blockade occurring in 120 min. The antiserum and heparin significantly prevented the neuromuscular blockade caused by BthTX-I (84 +/- 4% and 100% protection, respectively). Light microscopy examination of the muscles at the end of the 120 min incubation showed that BthTX-I damaged 48 +/- 6% of the fibers. Preincubating the toxin with antivenom significantly reduced the extent of this damage (only 15 +/- 4% of fibers affected, corresponding to 69% protection, P<0.01) whereas heparin offered no protection (34 +/- 7% of fibers affected, not significantly different from that seen with toxin alone). These results show that the antivenom was more effective in neutralizing the myotoxic effects of BthTX-I than was heparin." @default.
• W2077534140 created "2016-06-24" @default.
• W2077534140 creator A5017740319 @default.
• W2077534140 creator A5026279760 @default.
• W2077534140 creator A5040195743 @default.
• W2077534140 creator A5046590325 @default.
• W2077534140 creator A5050872911 @default.
• W2077534140 creator A5055613258 @default.
• W2077534140 creator A5076512109 @default.
• W2077534140 creator A5087454277 @default.
• W2077534140 date "2001-10-01" @default.
• W2077534140 modified "2023-10-14" @default.
• W2077534140 title "Neutralization of the pharmacological effects of bothropstoxin-I from Bothrops jararacussu (jararacuçu) venom by crotoxin antiserum and heparin" @default.
• W2077534140 cites W110993326 @default.
• W2077534140 cites W1534485474 @default.
• W2077534140 cites W1964748161 @default.
• W2077534140 cites W1968614376 @default.
• W2077534140 cites W1970838759 @default.
• W2077534140 cites W1972223614 @default.
• W2077534140 cites W1979660733 @default.
• W2077534140 cites W1980206863 @default.
• W2077534140 cites W1984821514 @default.
• W2077534140 cites W1999774962 @default.
• W2077534140 cites W2002744664 @default.
• W2077534140 cites W2043089565 @default.
• W2077534140 cites W2047955230 @default.
• W2077534140 cites W2069192830 @default.
• W2077534140 cites W2073921110 @default.
• W2077534140 cites W2081291984 @default.
• W2077534140 cites W2083357538 @default.
• W2077534140 cites W2087019136 @default.
• W2077534140 cites W2092340365 @default.
• W2077534140 cites W2092804900 @default.
• W2077534140 cites W2094063128 @default.
• W2077534140 cites W2095583307 @default.
• W2077534140 cites W2100837269 @default.
• W2077534140 cites W2102131116 @default.
• W2077534140 cites W2141002604 @default.
• W2077534140 cites W2167996960 @default.
• W2077534140 cites W2395412618 @default.
• W2077534140 doi "https://doi.org/10.1016/s0041-0101(01)00107-6" @default.
• W2077534140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11478955" @default.
• W2077534140 hasPublicationYear "2001" @default.
• W2077534140 type Work @default.
• W2077534140 sameAs 2077534140 @default.
• W2077534140 citedByCount "38" @default.
• W2077534140 countsByYear W20775341402012 @default.
• W2077534140 countsByYear W20775341402013 @default.
• W2077534140 countsByYear W20775341402014 @default.
• W2077534140 countsByYear W20775341402016 @default.
• W2077534140 countsByYear W20775341402017 @default.
• W2077534140 countsByYear W20775341402018 @default.
• W2077534140 countsByYear W20775341402020 @default.
• W2077534140 countsByYear W20775341402023 @default.
• W2077534140 crossrefType "journal-article" @default.
• W2077534140 hasAuthorship W2077534140A5017740319 @default.
• W2077534140 hasAuthorship W2077534140A5026279760 @default.
• W2077534140 hasAuthorship W2077534140A5040195743 @default.
• W2077534140 hasAuthorship W2077534140A5046590325 @default.
• W2077534140 hasAuthorship W2077534140A5050872911 @default.
• W2077534140 hasAuthorship W2077534140A5055613258 @default.
• W2077534140 hasAuthorship W2077534140A5076512109 @default.
• W2077534140 hasAuthorship W2077534140A5087454277 @default.
• W2077534140 hasConcept C117287731 @default.
• W2077534140 hasConcept C14086860 @default.
• W2077534140 hasConcept C159654299 @default.
• W2077534140 hasConcept C185592680 @default.
• W2077534140 hasConcept C203014093 @default.
• W2077534140 hasConcept C2776725428 @default.
• W2077534140 hasConcept C2777557582 @default.
• W2077534140 hasConcept C2779448229 @default.
• W2077534140 hasConcept C2779815518 @default.
• W2077534140 hasConcept C2909465803 @default.
• W2077534140 hasConcept C42219234 @default.
• W2077534140 hasConcept C55493867 @default.
• W2077534140 hasConcept C71924100 @default.
• W2077534140 hasConcept C91523082 @default.
• W2077534140 hasConcept C97664909 @default.
• W2077534140 hasConcept C98274493 @default.
• W2077534140 hasConceptScore W2077534140C117287731 @default.
• W2077534140 hasConceptScore W2077534140C14086860 @default.
• W2077534140 hasConceptScore W2077534140C159654299 @default.
• W2077534140 hasConceptScore W2077534140C185592680 @default.
• W2077534140 hasConceptScore W2077534140C203014093 @default.
• W2077534140 hasConceptScore W2077534140C2776725428 @default.
• W2077534140 hasConceptScore W2077534140C2777557582 @default.
• W2077534140 hasConceptScore W2077534140C2779448229 @default.
• W2077534140 hasConceptScore W2077534140C2779815518 @default.
• W2077534140 hasConceptScore W2077534140C2909465803 @default.
• W2077534140 hasConceptScore W2077534140C42219234 @default.
• W2077534140 hasConceptScore W2077534140C55493867 @default.
• W2077534140 hasConceptScore W2077534140C71924100 @default.
• W2077534140 hasConceptScore W2077534140C91523082 @default.
• W2077534140 hasConceptScore W2077534140C97664909 @default.
• W2077534140 hasConceptScore W2077534140C98274493 @default.
• W2077534140 hasIssue "10" @default.
• W2077534140 hasLocation W20775341401 @default.
• W2077534140 hasLocation W20775341402 @default.

• next