FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077537745> ?p ?o ?g. }

• W2077537745 endingPage "9744" @default.
• W2077537745 startingPage "9744" @default.
• W2077537745 abstract "Chiral separation is an important issue in pharmaceutical research and industries, because most organic compounds and biological molecules, including many drugs and food additives, are chiral compounds. DNA aptamers are a new group of chiral selectors; however, there still exists deficiencies in the understanding of the molecular basis of their chiral recognition. Herein, a comparative study of the DNA aptamer binding with L-argininamide (L-Arm) and its enantiomer (D-Arm) is investigated by spectroscopic and calorimetric methods. The effect of various experimental conditions such as temperature, pH and salt concentration on the L-Arm and D-Arm binding properties was studied in order to provide information about the chiral recognition mechanism of the DNA aptamer. An isothermal titration calorimetry study reveals that both L-Arm and D-Arm binding with the aptamer are enthalpy driven and entropy cost processes. The protonated amino group of both L-Arm and D-Arm participates in electrostatic interaction and this interaction is stronger for D-Arm than L-Arm binding with the aptamer. From the opposite behavior of the heat capacity change of the two enantiomers, we could suggest that L-Arm and D-Arm bind at different binding sites of the aptamer, resulting in different conformations of the binding complexes. In the binding mechanism, electrostatic interaction provided by the protonated amino group with the aptamer and the conformational change of the nucleic acid upon binding are major processes involved for chiral recognition in the DNA aptamer. This study provides information on chiral separation of D- and L-argininamide by the aptamer, which can be successfully achieved by varying the operation temperature based on the opposite heat capacity dependence of the enantiomers binding with the DNA." @default.
• W2077537745 created "2016-06-24" @default.
• W2077537745 creator A5012321811 @default.
• W2077537745 creator A5014557242 @default.
• W2077537745 creator A5020437579 @default.
• W2077537745 creator A5087082348 @default.
• W2077537745 creator A5089927641 @default.
• W2077537745 date "2009-01-01" @default.
• W2077537745 modified "2023-10-18" @default.
• W2077537745 title "Thermodynamic basis of chiral recognition in a DNA aptamer" @default.
• W2077537745 cites W1964063567 @default.
• W2077537745 cites W1964332275 @default.
• W2077537745 cites W1964946948 @default.
• W2077537745 cites W1965127482 @default.
• W2077537745 cites W1970320247 @default.
• W2077537745 cites W1987407720 @default.
• W2077537745 cites W1999599916 @default.
• W2077537745 cites W2001129137 @default.
• W2077537745 cites W2004335248 @default.
• W2077537745 cites W2026884660 @default.
• W2077537745 cites W2030523051 @default.
• W2077537745 cites W2032367398 @default.
• W2077537745 cites W2035738941 @default.
• W2077537745 cites W2036150293 @default.
• W2077537745 cites W2041715180 @default.
• W2077537745 cites W2041971300 @default.
• W2077537745 cites W2066314417 @default.
• W2077537745 cites W2069514224 @default.
• W2077537745 cites W2079321730 @default.
• W2077537745 cites W2081133820 @default.
• W2077537745 cites W2085012865 @default.
• W2077537745 cites W2089483097 @default.
• W2077537745 cites W2090545729 @default.
• W2077537745 cites W2090905113 @default.
• W2077537745 cites W2093583318 @default.
• W2077537745 cites W2094034119 @default.
• W2077537745 cites W2096048289 @default.
• W2077537745 cites W2104525153 @default.
• W2077537745 cites W2142182637 @default.
• W2077537745 cites W2153207080 @default.
• W2077537745 cites W2163555337 @default.
• W2077537745 cites W2170493214 @default.
• W2077537745 cites W65628087 @default.
• W2077537745 doi "https://doi.org/10.1039/b907763d" @default.
• W2077537745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19851552" @default.
• W2077537745 hasPublicationYear "2009" @default.
• W2077537745 type Work @default.
• W2077537745 sameAs 2077537745 @default.
• W2077537745 citedByCount "28" @default.
• W2077537745 countsByYear W20775377452012 @default.
• W2077537745 countsByYear W20775377452013 @default.
• W2077537745 countsByYear W20775377452014 @default.
• W2077537745 countsByYear W20775377452015 @default.
• W2077537745 countsByYear W20775377452016 @default.
• W2077537745 countsByYear W20775377452017 @default.
• W2077537745 countsByYear W20775377452018 @default.
• W2077537745 countsByYear W20775377452020 @default.
• W2077537745 countsByYear W20775377452022 @default.
• W2077537745 crossrefType "journal-article" @default.
• W2077537745 hasAuthorship W2077537745A5012321811 @default.
• W2077537745 hasAuthorship W2077537745A5014557242 @default.
• W2077537745 hasAuthorship W2077537745A5020437579 @default.
• W2077537745 hasAuthorship W2077537745A5087082348 @default.
• W2077537745 hasAuthorship W2077537745A5089927641 @default.
• W2077537745 hasConcept C128972844 @default.
• W2077537745 hasConcept C145148216 @default.
• W2077537745 hasConcept C156911925 @default.
• W2077537745 hasConcept C178790620 @default.
• W2077537745 hasConcept C179303850 @default.
• W2077537745 hasConcept C185592680 @default.
• W2077537745 hasConcept C21951064 @default.
• W2077537745 hasConcept C24107716 @default.
• W2077537745 hasConcept C30095370 @default.
• W2077537745 hasConcept C32909587 @default.
• W2077537745 hasConcept C486523 @default.
• W2077537745 hasConcept C54355233 @default.
• W2077537745 hasConcept C552990157 @default.
• W2077537745 hasConcept C55493867 @default.
• W2077537745 hasConcept C71240020 @default.
• W2077537745 hasConcept C86803240 @default.
• W2077537745 hasConceptScore W2077537745C128972844 @default.
• W2077537745 hasConceptScore W2077537745C145148216 @default.
• W2077537745 hasConceptScore W2077537745C156911925 @default.
• W2077537745 hasConceptScore W2077537745C178790620 @default.
• W2077537745 hasConceptScore W2077537745C179303850 @default.
• W2077537745 hasConceptScore W2077537745C185592680 @default.
• W2077537745 hasConceptScore W2077537745C21951064 @default.
• W2077537745 hasConceptScore W2077537745C24107716 @default.
• W2077537745 hasConceptScore W2077537745C30095370 @default.
• W2077537745 hasConceptScore W2077537745C32909587 @default.
• W2077537745 hasConceptScore W2077537745C486523 @default.
• W2077537745 hasConceptScore W2077537745C54355233 @default.
• W2077537745 hasConceptScore W2077537745C552990157 @default.
• W2077537745 hasConceptScore W2077537745C55493867 @default.
• W2077537745 hasConceptScore W2077537745C71240020 @default.
• W2077537745 hasConceptScore W2077537745C86803240 @default.
• W2077537745 hasIssue "42" @default.
• W2077537745 hasLocation W20775377451 @default.

• next