FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077545713> ?p ?o ?g. }

• W2077545713 abstract "Abstract Objective To elucidate distinct functions of a recently identified cancer metastasis-associated molecule, related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) in the mammalian immune system. Methods Immunohistochemical assays and functional analysis on the immune system were performed on RTVP –/– mice and RTVP-1 +/+ mice. Protein-protein interaction (PPI) was used to predict the functions of RTVP-1. Results Abnormal lymphocyte growth kinetics and reduced numbers of CD8 + T cells were revealed in lymph nodes of RTVP-1 –/– mice. Expression of phenotypic markers of maturation in bone marrow-derived dendritic cells (DC) was impaired in RTVP-1 –/– DC following antigenic stimulation in vitro and RTVP-1 –/– DC failed to provide normal CD4 + T cell stimulatory activities in vivo . RTVP-1 –/– mice failed to generate normal CTL or antibody responses in vivo after vaccination. In vivo tumor challenge experiments using a mouse cancer cell line demonstrated that the growth rate of subcutaneous tumors in RTVP-1 –/– mice was significantly increased and CD8 + T cell infiltration significantly reduced compared to RTVP-1 +/+ mice. PPI showed that RTVP-1 protein closely interacted with molecules associated with immune response and cancer metastasis. Conclusion RTVP-1 might function as a tumor metastasis suppressor and immunosurveillance molecule in cancer." @default.
• W2077545713 created "2016-06-24" @default.
• W2077545713 creator A5030583882 @default.
• W2077545713 creator A5030927828 @default.
• W2077545713 creator A5032001329 @default.
• W2077545713 creator A5037377300 @default.
• W2077545713 creator A5042000405 @default.
• W2077545713 creator A5049464184 @default.
• W2077545713 creator A5072964389 @default.
• W2077545713 creator A5073114988 @default.
• W2077545713 creator A5083157583 @default.
• W2077545713 creator A5083466095 @default.
• W2077545713 date "2008-08-01" @default.
• W2077545713 modified "2023-09-26" @default.
• W2077545713 title "Roles of a metastasis-associated molecule, RTVP-1, in cancer immunosurveillance" @default.
• W2077545713 cites W1494836084 @default.
• W2077545713 cites W1598843567 @default.
• W2077545713 cites W1965771018 @default.
• W2077545713 cites W1992316410 @default.
• W2077545713 cites W1992626042 @default.
• W2077545713 cites W1996361953 @default.
• W2077545713 cites W2006800189 @default.
• W2077545713 cites W2016666932 @default.
• W2077545713 cites W2039696496 @default.
• W2077545713 cites W2046972425 @default.
• W2077545713 cites W2052233102 @default.
• W2077545713 cites W2095864883 @default.
• W2077545713 cites W2109411143 @default.
• W2077545713 cites W2118316119 @default.
• W2077545713 cites W2122907368 @default.
• W2077545713 cites W2129728624 @default.
• W2077545713 cites W2156188054 @default.
• W2077545713 cites W2161798988 @default.
• W2077545713 cites W2168401998 @default.
• W2077545713 doi "https://doi.org/10.1016/s1000-1948(08)60042-8" @default.
• W2077545713 hasPublicationYear "2008" @default.
• W2077545713 type Work @default.
• W2077545713 sameAs 2077545713 @default.
• W2077545713 citedByCount "0" @default.
• W2077545713 crossrefType "journal-article" @default.
• W2077545713 hasAuthorship W2077545713A5030583882 @default.
• W2077545713 hasAuthorship W2077545713A5030927828 @default.
• W2077545713 hasAuthorship W2077545713A5032001329 @default.
• W2077545713 hasAuthorship W2077545713A5037377300 @default.
• W2077545713 hasAuthorship W2077545713A5042000405 @default.
• W2077545713 hasAuthorship W2077545713A5049464184 @default.
• W2077545713 hasAuthorship W2077545713A5072964389 @default.
• W2077545713 hasAuthorship W2077545713A5073114988 @default.
• W2077545713 hasAuthorship W2077545713A5083157583 @default.
• W2077545713 hasAuthorship W2077545713A5083466095 @default.
• W2077545713 hasConcept C121608353 @default.
• W2077545713 hasConcept C147969180 @default.
• W2077545713 hasConcept C150903083 @default.
• W2077545713 hasConcept C167672396 @default.
• W2077545713 hasConcept C203014093 @default.
• W2077545713 hasConcept C207001950 @default.
• W2077545713 hasConcept C2776090121 @default.
• W2077545713 hasConcept C2776885095 @default.
• W2077545713 hasConcept C2779013556 @default.
• W2077545713 hasConcept C2779540182 @default.
• W2077545713 hasConcept C502942594 @default.
• W2077545713 hasConcept C54355233 @default.
• W2077545713 hasConcept C86803240 @default.
• W2077545713 hasConcept C8891405 @default.
• W2077545713 hasConceptScore W2077545713C121608353 @default.
• W2077545713 hasConceptScore W2077545713C147969180 @default.
• W2077545713 hasConceptScore W2077545713C150903083 @default.
• W2077545713 hasConceptScore W2077545713C167672396 @default.
• W2077545713 hasConceptScore W2077545713C203014093 @default.
• W2077545713 hasConceptScore W2077545713C207001950 @default.
• W2077545713 hasConceptScore W2077545713C2776090121 @default.
• W2077545713 hasConceptScore W2077545713C2776885095 @default.
• W2077545713 hasConceptScore W2077545713C2779013556 @default.
• W2077545713 hasConceptScore W2077545713C2779540182 @default.
• W2077545713 hasConceptScore W2077545713C502942594 @default.
• W2077545713 hasConceptScore W2077545713C54355233 @default.
• W2077545713 hasConceptScore W2077545713C86803240 @default.
• W2077545713 hasConceptScore W2077545713C8891405 @default.
• W2077545713 hasLocation W20775457131 @default.
• W2077545713 hasOpenAccess W2077545713 @default.
• W2077545713 hasPrimaryLocation W20775457131 @default.
• W2077545713 hasRelatedWork W1010975229 @default.
• W2077545713 hasRelatedWork W1894032769 @default.
• W2077545713 hasRelatedWork W1967042587 @default.
• W2077545713 hasRelatedWork W1986175403 @default.
• W2077545713 hasRelatedWork W2032132964 @default.
• W2077545713 hasRelatedWork W2068180152 @default.
• W2077545713 hasRelatedWork W2068342722 @default.
• W2077545713 hasRelatedWork W2086986382 @default.
• W2077545713 hasRelatedWork W2093892510 @default.
• W2077545713 hasRelatedWork W2128390153 @default.
• W2077545713 hasRelatedWork W2129572376 @default.
• W2077545713 hasRelatedWork W2145092923 @default.
• W2077545713 hasRelatedWork W2151062082 @default.
• W2077545713 hasRelatedWork W2383904614 @default.
• W2077545713 hasRelatedWork W2391509944 @default.
• W2077545713 hasRelatedWork W2593994335 @default.
• W2077545713 hasRelatedWork W2725962181 @default.
• W2077545713 hasRelatedWork W2740533374 @default.
• W2077545713 hasRelatedWork W2996134094 @default.

• next