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• W2077547710 endingPage "129" @default.
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• W2077547710 abstract "DNA packaging into nucleosomes presents a barrier to many motor proteins, including the transcriptional machinery. By unzipping DNA in single nucleosomes, a detailed map at near base pair resolution of histone-DNA interactions is now provided, suggesting that interaction with the two DNA strands is decoupled and that unraveling past the dyad axis of the nucleosome, as might occur when a motor protein passes through, is sufficient to displace histones. The nature of the nucleosomal barrier that regulates access to the underlying DNA during many cellular processes is not fully understood. Here we present a detailed map of histone-DNA interactions along the DNA sequence to near base pair accuracy by mechanically unzipping single molecules of DNA, each containing a single nucleosome. This interaction map revealed a distinct ∼5-bp periodicity that was enveloped by three broad regions of strong interactions, with the strongest occurring at the dyad and the other two about ±40-bp from the dyad. Unzipping up to the dyad allowed recovery of a canonical nucleosome upon relaxation of the DNA, but unzipping beyond the dyad resulted in removal of the histone octamer from its initial DNA sequence. These findings have important implications for how RNA polymerase and other DNA-based enzymes may gain access to DNA associated with a nucleosome." @default.
• W2077547710 created "2016-06-24" @default.
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• W2077547710 date "2009-01-11" @default.
• W2077547710 modified "2023-10-14" @default.
• W2077547710 title "High-resolution dynamic mapping of histone-DNA interactions in a nucleosome" @default.
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• W2077547710 doi "https://doi.org/10.1038/nsmb.1526" @default.
• W2077547710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2635915" @default.
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• W2077547710 hasPublicationYear "2009" @default.
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