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• W2077552045 startingPage "485" @default.
• W2077552045 abstract "Significance: Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme that oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide. Tumor cells may take advantage of oxidative environments at different stages of tumorigenesis, but QSOX1 may also serve additional functions in tumors. Recent Advances: Several groups have reported the over-expression of QSOX1 in breast, pancreas, and prostate cancers. A consensus is building that QSOX1 over-expression is important during tumor cell invasion, facilitating tumor cell migration at the tumor-stroma interface. As such, QSOX1 may be considered a prognostic indicator of metastatic potential or even indicate that cancer is present in a host. Critical Issues: However, some controversy exists between QSOX1 as a marker of poor or favorable outcome in breast cancer. More studies are required to reveal what advantage QSOX1 provides to breast and other types of cancer. More specifically, it is critical to learn which tumor types over-express QSOX1 and use its enzymatic activity to their advantage. Future Directions: As interest increases in understanding the mechanisms of tumorigenesis within the extracellular matrix and how tumor cells influence fibroblasts and other stromal cells, QSOX1 may be revealed as an important player in cancer detection and prognosis. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo models will provide important insights into how to target QSOX1 with anti-neoplastic agents. Antioxid. Redox Signal. 21, 485–496." @default.
• W2077552045 created "2016-06-24" @default.
• W2077552045 creator A5077198178 @default.
• W2077552045 creator A5086127613 @default.
• W2077552045 date "2014-07-20" @default.
• W2077552045 modified "2023-10-11" @default.
• W2077552045 title "The Emerging Role of QSOX1 in Cancer" @default.
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• W2077552045 doi "https://doi.org/10.1089/ars.2013.5572" @default.
• W2077552045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4076994" @default.
• W2077552045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24359107" @default.
• W2077552045 hasPublicationYear "2014" @default.
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