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- W2077554711 abstract "Electric Status Epilepticus during Sleep (ESES) occurs in children with and without epilepsy. It may be related to disturbances as autism spectrum disorder, attention-deficit hyperactivity disorder and acquired aphasia (Landau-Kleffner syndrome). Antiepileptic drug (AED) treatment has been reported in small studies without placebo control. This study was designed to assess AED effect in a placebo-controlled double-blind cross-over study. Levetiracetam (LEV) was chosen based on clinical evidence. Eighteen patients fulfilled the inclusion criteria. The mean spike index at baseline was 56, falling to a mean of 37 at the end of the LEV treatment period. Assessed with a 2-way ANOVA, there is a significant treatment effect (p<0.0002). To the best of our knowledge, this is the first placebo-controlled double-blind cross-over study for any AED in patients with ESES. The effect of LEV is comparable with its effect in treatment of epileptic seizures." @default.
- W2077554711 created "2016-06-24" @default.
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- W2077554711 date "2012-05-01" @default.
- W2077554711 modified "2023-09-27" @default.
- W2077554711 title "The effect of levetiracetam on focal nocturnal epileptiform activity during sleep — A placebo-controlled double-blind cross-over study" @default.
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- W2077554711 doi "https://doi.org/10.1016/j.yebeh.2012.02.024" @default.
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