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• W2077554795 abstract "X-ray structures permit theoretical study of Cl− permeation along bacterial ClC Cl− pores. We determined the lowest energy curvilinear pathway, identified anion-coordinating amino acids, and calculated the electrostatic potential energy profiles. We find that all four bacterial ClC Cl− crystal structures correspond to closed states. E148 and S107 side chains form steric barriers on both sides of the crystal binding site in the StClC wild-type and EcClC wild-type crystals; both the EcClC(E148A) and EcClC(E148Q) mutants are blocked at the S107 site. We studied the effect that mutating the charge of some strongly conserved pore-lining amino acids has on the electrostatic potential energy profiles. When E148 is neutralized, it creates an electrostatic trap, binding the ion near midmembrane. This suggests a possible electrostatic mechanism for controlling anion flow: neutralize E148, displace the side chain of E148 from the pore pathway to relieve the steric barrier, then trap the anion at midmembrane, and finally either deprotonate E148 and block the pore (pore closure) or bring a second Cl− into the pore to promote anion flow (pore conductance). Side-chain displacement may arise by competition for the binding site between the oxygens of E148 and the anion moving down the electrostatic energy gradient. We also find that the charge state of E111 and E113 may electrostatically control anion conductance and occupancy of the binding site within the cytoplasmic pore." @default.
• W2077554795 created "2016-06-24" @default.
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• W2077554795 creator A5058210937 @default.
• W2077554795 date "2004-02-01" @default.
• W2077554795 modified "2023-10-16" @default.
• W2077554795 title "Anion Pathway and Potential Energy Profiles along Curvilinear Bacterial ClC Cl− Pores: Electrostatic Effects of Charged Residues" @default.
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• W2077554795 doi "https://doi.org/10.1016/s0006-3495(04)74158-2" @default.
• W2077554795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1303930" @default.
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