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- W2077556505 abstract "Abstract Silkworm, Bombyx mori , produces self-denfense substance lepidopteran in a haemolymph when it is vaccinated with killed Escherichia coli . Lepidopteran family contains at least three congeners A, B and C, all of which were isolated and determined in amino acid sequences. Furthermore, total synthesis of lepidopteran A was achieved. For elucidation of structure-activity relationship of lepidopteran, twenty one different kinds of peptide fragments were then synthesized. From results of antibacterial tests for those peptides, it is concluded that N-terminal region particularly the Arg -Trp2 sequence is very important for exhibition of the biological activity. The minimal sequence of lepidopteran providing significant bioactivity is the peptide fragment (1–18). α-Helix content in the peptide chain does not necessarily guarantee a manifestation of the activity. An important factor to strengthen the activity seems to be a hydrophobicity in the molecule in addition to the N-terminal region. The assumption was confirmed by preparation of long aliphatic amide of the fragment (1–18) which showed almost comparable activity to that of the original lepidopteran." @default.
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- W2077556505 date "1988-01-01" @default.
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- W2077556505 title "Structure-activity relationship of lepidopteran, a self-defence peptide of bombyx moriXXX" @default.
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- W2077556505 doi "https://doi.org/10.1016/s0040-4020(01)86117-2" @default.
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