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• W2077560317 abstract "We have previously shown that retinoic acid (RA) has protective effects on high glucose (HG)-induced cardiomyocyte apoptosis. To further elucidate the molecular mechanisms of RA effects, we determined the interaction between nuclear factor (NF)-κB and RA signaling. HG induced a sustained phosphorylation of IKK/IκBα and transcriptional activation of NF-κB in cardiomyocytes. Activated NF-κB signaling has an important role in HG-induced cardiomyocyte apoptosis and gene expression of interleukin-6 (IL-6), tumor necrosis factor (TNF)-α, and monocyte chemoattractant protein-1 (MCP-1). All-trans RA (ATRA) and LGD1069, through activation of RAR/RXR-mediated signaling, inhibited the HG-mediated effects in cardiomyocytes. The inhibitory effect of RA on NF-κB activation was mediated through inhibition of IKK/IκBα phosphorylation. ATRA and LGD1069 treatment promoted protein phosphatase 2A (PP2A) activity, which was significantly suppressed by HG stimulation. The RA effects on IKK and IκBα were blocked by okadaic acid or silencing the expression of PP2Ac-subunit, indicating that the inhibitory effect of RA on NF-κB is regulated through activation of PP2A and subsequent dephosphorylation of IKK/IκBα. Moreover, ATRA and LGD1069 reversed the decreased PP2A activity and inhibited the activation of IKK/IκBα and gene expression of MCP-1, IL-6, and TNF-α in the hearts of Zucker diabetic fatty rats. In summary, our findings suggest that the suppressed activation of PP2A contributed to sustained activation of NF-κB in HG-stimulated cardiomyocytes; and that the protective effect of RA on hyperglycemia-induced cardiomyocyte apoptosis and inflammatory responses is partially regulated through activation of PP2A and suppression of NF-κB-mediated signaling and downstream targets. J. Cell. Physiol. 228: 380–392, 2013. © 2012 Wiley Periodicals, Inc." @default.
• W2077560317 created "2016-06-24" @default.
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• W2077560317 date "2012-10-25" @default.
• W2077560317 modified "2023-09-29" @default.
• W2077560317 title "Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-κB signaling Pathway" @default.
• W2077560317 cites W1499540451 @default.
• W2077560317 cites W1532865172 @default.
• W2077560317 cites W1600472471 @default.
• W2077560317 cites W1641228030 @default.
• W2077560317 cites W1661180389 @default.
• W2077560317 cites W1926205250 @default.
• W2077560317 cites W1950169838 @default.
• W2077560317 cites W1964631519 @default.
• W2077560317 cites W1970527212 @default.
• W2077560317 cites W1973491531 @default.
• W2077560317 cites W1976382352 @default.
• W2077560317 cites W1978213355 @default.
• W2077560317 cites W1982838890 @default.
• W2077560317 cites W1983805610 @default.
• W2077560317 cites W1988618725 @default.
• W2077560317 cites W1992564227 @default.
• W2077560317 cites W1995572919 @default.
• W2077560317 cites W1997664222 @default.
• W2077560317 cites W1998986309 @default.
• W2077560317 cites W2001280219 @default.
• W2077560317 cites W2013730613 @default.
• W2077560317 cites W2017405235 @default.
• W2077560317 cites W2023407429 @default.
• W2077560317 cites W2032524530 @default.
• W2077560317 cites W2037264667 @default.
• W2077560317 cites W2041626380 @default.
• W2077560317 cites W2046670415 @default.
• W2077560317 cites W2048622861 @default.
• W2077560317 cites W2054312934 @default.
• W2077560317 cites W2055904430 @default.
• W2077560317 cites W2060136890 @default.
• W2077560317 cites W2065691971 @default.
• W2077560317 cites W2066688646 @default.
• W2077560317 cites W2066856908 @default.
• W2077560317 cites W2069988274 @default.
• W2077560317 cites W2073882423 @default.
• W2077560317 cites W2082268272 @default.
• W2077560317 cites W2085078083 @default.
• W2077560317 cites W2086667809 @default.
• W2077560317 cites W2089342328 @default.
• W2077560317 cites W2098710866 @default.
• W2077560317 cites W2107164329 @default.
• W2077560317 cites W2108713413 @default.
• W2077560317 cites W2117374716 @default.
• W2077560317 cites W2119361029 @default.
• W2077560317 cites W2121316694 @default.
• W2077560317 cites W2125409892 @default.
• W2077560317 cites W2132243068 @default.
• W2077560317 cites W2133982451 @default.
• W2077560317 cites W2138911901 @default.
• W2077560317 cites W2140125389 @default.
• W2077560317 cites W2145461802 @default.
• W2077560317 cites W2145634315 @default.
• W2077560317 cites W2147921405 @default.
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• W2077560317 cites W2152973003 @default.
• W2077560317 cites W2153092921 @default.
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• W2077560317 cites W2162347636 @default.
• W2077560317 cites W2168832391 @default.
• W2077560317 cites W2170537843 @default.
• W2077560317 cites W2316580498 @default.
• W2077560317 cites W2320874640 @default.
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• W2077560317 doi "https://doi.org/10.1002/jcp.24142" @default.
• W2077560317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3470832" @default.
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