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- W2077561497 abstract "Adopting multi-donors to pair with one acceptor could improve the performance of fluorogenic detection probes. However, common dyes (e.g., fluorescein) in close proximity to each other would self-quench the fluorescence, and the fluorescence is difficult to restore. In this contribution, we constructed a novel multi-donors-to-one acceptor fluorescent DNA detection system by means of the intermolecular G-quadruplex (IGQ) structure-based fluorescence signal enhancement combined with the hairpin oligonucleotide. The novel IGQ-hairpin system was characterized using the p53 gene as the model target DNA. The proposed system showed an improved assay performance due to the introduction of IGQ-structure into fluorescent signaling probes, which could inhibit the background fluorescence and increase fluorescence restoration amplitude of fluoresceins upon target DNA hybridization. The proof-of-concept scheme is expected to provide new insight into the potential of G-quadruplex structure and promote the application of fluorescent oligonucleotide probes in fundamental research, diagnosis, and treatment of genetic diseases." @default.
- W2077561497 created "2016-06-24" @default.
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- W2077561497 date "2013-03-01" @default.
- W2077561497 modified "2023-10-15" @default.
- W2077561497 title "Intermolecular G-quadruplex structure-based fluorescent DNA detection system" @default.
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- W2077561497 doi "https://doi.org/10.1016/j.bios.2012.08.028" @default.
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