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- W2077573175 abstract "Concerns of a tumorigenic risk of styrene (ST) originate from the findings that styrene (ST) is metabolized to the genotoxic intermediate styrene-7,8-oxide (SO). Therefore, it was hypothesized that results of animal long-term studies with ST and SO together with the SO tissue burden are sufficient for conducting a ‘worst case’ estimate of the tumorigenic risk of ST. On this basis we predicted the excess human lifetime risk for lung tumors (pEXL) and the highest possible risk for other systemic tumors (pHPS) resulting from daily intake of ST via food and ambient air. As measures for pEXL the mean lifetime concentration of SO in the transitional zone of the lung and for pHPS the mean lifetime concentration of SO in blood were calculated using a physiological toxicokinetic model. For a daily oral intake of 12 μg ST, pEXL was obtained to be between 5×10−9 and 2×10−8 and pHPS to be between 7×10−9 and 2×10−8. Lifetime risks calculated for continuous exposure to 3 μg/m3 ST in ambient air were between 8×10−7 and 3×10−6 (pEXL) and between 2×10−8 and 4×10−8 (pHPS). Although these values indicate very low risks, the actual risks are expected to be even by far smaller. This is discussed in detail for lung tumorigenesis." @default.
- W2077573175 created "2016-06-24" @default.
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- W2077573175 date "2002-01-01" @default.
- W2077573175 modified "2023-09-27" @default.
- W2077573175 title "Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient air" @default.
- W2077573175 cites W1964311391 @default.
- W2077573175 cites W1968129420 @default.
- W2077573175 cites W1968934356 @default.
- W2077573175 cites W1969617712 @default.
- W2077573175 cites W1971515520 @default.
- W2077573175 cites W1972753289 @default.
- W2077573175 cites W1977998112 @default.
- W2077573175 cites W1978970842 @default.
- W2077573175 cites W1979609624 @default.
- W2077573175 cites W1979616133 @default.
- W2077573175 cites W1980530742 @default.
- W2077573175 cites W1981826066 @default.
- W2077573175 cites W1984526747 @default.
- W2077573175 cites W1987213613 @default.
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- W2077573175 cites W1993433081 @default.
- W2077573175 cites W1996270253 @default.
- W2077573175 cites W1998462172 @default.
- W2077573175 cites W2003288821 @default.
- W2077573175 cites W2009195606 @default.
- W2077573175 cites W2016478454 @default.
- W2077573175 cites W2017850766 @default.
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- W2077573175 doi "https://doi.org/10.1016/s0378-4274(01)00420-9" @default.
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