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- W2077576172 abstract "The influence of the sleep-awake cycle of the rat on the apparent hypnotic effects of two benzodiazepine hypnotics, triazolam (short half-life) and flurazepam (long half-life), was assessed. Cortical electroencephalographic recordings from freely moving animals were used to determine whether the rats were awake or asleep. When tested during the dark phase of the light-dark cycle, when rats sleep approximately 50% of each hour, both agents increased sleep, with flurazepam having a longer duration of action than triazolam. In contrast, when tested during the light phase of the light-dark cycle, when rats sleep approximately 70–90% of each hour, the sleep-inducing effects of the two agents could not be distinguished. These data emphasize the importance of baseline levels of sleep in assessing hypnotic-drug effects." @default.
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- W2077576172 date "1988-01-01" @default.
- W2077576172 modified "2023-09-27" @default.
- W2077576172 title "Assessment of hypnotic effects in the rat: Influence of the sleep-awake cycle" @default.
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- W2077576172 doi "https://doi.org/10.1002/ddr.430140206" @default.
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