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• W2077584192 abstract "Epilepsy characterized by repeated seizures is influenced by genetic factors. Seizure response of inbred mouse strains changes depending on the variety of stimuli including chemical (e.g., pentylenetetrazole, nicotine, cocaine, NMDA, kainate), physical (e.g., auditory) or electrical. In this study, we compared the susceptibilities of C57BL/6 and BALB/c mice strains to penicillin induced epileptiform activity (a focally induced, experimental epilepsy model), by analyzing the spike onset latency, spike amplitude and spike frequency. The power spectrums of baseline EEGs were also investigated. We found no alterations of spike onset latencies between the C57 and BALB mice. However, spike amplitudes and spike frequencies were found to be higher in BALB mice than C57 mice. With regard to EEG power spectrum, absolute power of investigated bands was not different between the two strains. Interestingly, the relative power of all investigated bands differed significantly between two strains. The relative power of delta and theta was lower whereas relative power of alpha, beta and gamma was higher in C57 mice compared to BALB mice. In conclusion, our findings showed that BALB mice are more sensitive to penicillin induced epileptiform activity when compared to C57 strain." @default.
• W2077584192 created "2016-06-24" @default.
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• W2077584192 date "2011-10-01" @default.
• W2077584192 modified "2023-10-14" @default.
• W2077584192 title "Comparison of focally induced epileptiform activities in C57BL/6 and BALB/c mice by using in vivo EEG recording" @default.
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• W2077584192 doi "https://doi.org/10.1016/j.neulet.2011.09.030" @default.
• W2077584192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21964381" @default.
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