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- W2077585704 abstract "Abstract To assess and compare degradation rates, poly(70 L ‐lactide‐ co ‐30 DL ‐lactide) [P(L/DL)LA] and poly(85 L ‐lactide‐ co ‐15‐glycolide) (PLGA) copolymer degradation were studied in patients (maxillofacial region) and in vitro . Five patients of a total of 20 with 85:15 PLGA osteosyntheses, and 15 of a total of 60 with 70:30 P(L/DL)LA osteosyntheses, (10 females and 10 males, 26–55 years; mean, 33 years) underwent explantations after 3, 6, 9, 12, 18, and 24 months. Identical resorbables immersed in physiological buffer solution at 37°C were compared at identical intervals. P(L/DL)LA's initial average molecular weight of 45,000 decreased to 25,000 in patients (and to 21,000 in vitro ) after 6 months, and to 8000 in patients after 18 months. PLGA's average molecular weight decreased from 44,600 to 22,000 after 3 months in patients and in vitro, and to 11,000 in patients and 1300 in vitro at 6 months. In‐patient and in vitro glass‐transition temperatures decreased from ∼60°C to 50°C over 18 months. Crystallinity in explants was ≤ 4% in P(L/DL)LA throughout testing, and 16% and 30% in PLGA at 6 and 12 months, respectively. Both copolymers decomposed reliably in patients: 85:15 PLGA within 12 months and 70:30 P(L/DL)LA within 24 months on average ( p < 0.005), leaving only extremely small granules that powder upon finger touch. In vitro rates were significantly faster ( p < 0.005). Crystallinity associated with foreign‐body reactions was minor and did not inhibit decomposition. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006" @default.
- W2077585704 created "2016-06-24" @default.
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- W2077585704 date "2005-09-23" @default.
- W2077585704 modified "2023-10-17" @default.
- W2077585704 title "In-patient versusin vitro degradation of P(L/DL)LA and PLGA" @default.
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- W2077585704 doi "https://doi.org/10.1002/jbm.b.30388" @default.
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