FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077587951> ?p ?o ?g. }

• W2077587951 endingPage "587" @default.
• W2077587951 startingPage "579" @default.
• W2077587951 abstract "While most women with ovarian cancer will achieve complete remission after treatment, the majority will relapse within two years, highlighting the need for novel therapies. Cancer stem cells (CSC) have been identified in ovarian cancer and most other carcinomas as a small population of cells that can self-renew. CSC are more chemoresistant and radio-resistant than the bulk tumor cells; it is likely that CSC are responsible for relapse, the major problem in cancer treatment. CD133 has emerged as one of the most promising markers for CSC in ovarian cancer. The hypothesis driving this study is that despite their low numbers in ovarian cancer tumors, CSC can be eradicated using CD133 targeted therapy and tumor growth can be inhibited.Ovarian cancer cell lines were evaluated using flow cytometry for expression of CD133. In vitro viability studies with an anti-CD133 targeted toxin were performed on one of the cell lines, NIH:OVCAR5. The drug was tested in vivo using a stably transfected luciferase-expressing NIH:OVCAR5 subline in nude mice, so that tumor growth could be monitored by digital imaging in real time.Ovarian cancer cell lines showed 5.6% to 16.0% CD133 expression. dCD133KDEL inhibited the in vitro growth of NIH:OVCAR5 cells. Despite low numbers of CD133-expressing cells in the tumor population, intraperitoneal drug therapy caused a selective decrease in tumor progression in intraperitoneal NIH:OVCAR5-luc tumors.Directly targeting CSC that are a major cause of drug resistant tumor relapse with an anti-CD133 targeted toxin shows promise for ovarian cancer therapy." @default.
• W2077587951 created "2016-06-24" @default.
• W2077587951 creator A5000085125 @default.
• W2077587951 creator A5021840212 @default.
• W2077587951 creator A5033765780 @default.
• W2077587951 creator A5045561472 @default.
• W2077587951 creator A5046352938 @default.
• W2077587951 creator A5054046683 @default.
• W2077587951 creator A5070954278 @default.
• W2077587951 date "2013-09-01" @default.
• W2077587951 modified "2023-10-18" @default.
• W2077587951 title "Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression" @default.
• W2077587951 cites W101497454 @default.
• W2077587951 cites W1964347636 @default.
• W2077587951 cites W1966354133 @default.
• W2077587951 cites W1975881545 @default.
• W2077587951 cites W1979830686 @default.
• W2077587951 cites W1982390113 @default.
• W2077587951 cites W1983961550 @default.
• W2077587951 cites W1997280228 @default.
• W2077587951 cites W1997523587 @default.
• W2077587951 cites W1998056948 @default.
• W2077587951 cites W1999356404 @default.
• W2077587951 cites W1999661314 @default.
• W2077587951 cites W2000035739 @default.
• W2077587951 cites W2001177731 @default.
• W2077587951 cites W2001626604 @default.
• W2077587951 cites W2009207741 @default.
• W2077587951 cites W2014418809 @default.
• W2077587951 cites W2015244252 @default.
• W2077587951 cites W2017975901 @default.
• W2077587951 cites W2019865561 @default.
• W2077587951 cites W2030329983 @default.
• W2077587951 cites W2033364737 @default.
• W2077587951 cites W2035880310 @default.
• W2077587951 cites W2038004616 @default.
• W2077587951 cites W2041700684 @default.
• W2077587951 cites W2043103956 @default.
• W2077587951 cites W2049182264 @default.
• W2077587951 cites W2049762173 @default.
• W2077587951 cites W2051055358 @default.
• W2077587951 cites W2051239163 @default.
• W2077587951 cites W2062069198 @default.
• W2077587951 cites W2062921969 @default.
• W2077587951 cites W2064212361 @default.
• W2077587951 cites W2067067209 @default.
• W2077587951 cites W2074082353 @default.
• W2077587951 cites W2074954684 @default.
• W2077587951 cites W2074982201 @default.
• W2077587951 cites W2077223423 @default.
• W2077587951 cites W2083998563 @default.
• W2077587951 cites W2088635881 @default.
• W2077587951 cites W2094040645 @default.
• W2077587951 cites W2094829108 @default.
• W2077587951 cites W2096584091 @default.
• W2077587951 cites W2098516100 @default.
• W2077587951 cites W2101810527 @default.
• W2077587951 cites W2108383176 @default.
• W2077587951 cites W2110170406 @default.
• W2077587951 cites W2111618277 @default.
• W2077587951 cites W2112197935 @default.
• W2077587951 cites W2118546583 @default.
• W2077587951 cites W2121980133 @default.
• W2077587951 cites W2126712477 @default.
• W2077587951 cites W2127422682 @default.
• W2077587951 cites W2130552015 @default.
• W2077587951 cites W2134715788 @default.
• W2077587951 cites W2137795228 @default.
• W2077587951 cites W2138784667 @default.
• W2077587951 cites W2139907615 @default.
• W2077587951 cites W2141437534 @default.
• W2077587951 cites W2155156801 @default.
• W2077587951 cites W2155522744 @default.
• W2077587951 cites W2160272971 @default.
• W2077587951 cites W2162647147 @default.
• W2077587951 cites W2166424982 @default.
• W2077587951 cites W2170162759 @default.
• W2077587951 cites W2205733027 @default.
• W2077587951 doi "https://doi.org/10.1016/j.ygyno.2013.05.027" @default.
• W2077587951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3906852" @default.
• W2077587951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23721800" @default.
• W2077587951 hasPublicationYear "2013" @default.
• W2077587951 type Work @default.
• W2077587951 sameAs 2077587951 @default.
• W2077587951 citedByCount "84" @default.
• W2077587951 countsByYear W20775879512013 @default.
• W2077587951 countsByYear W20775879512014 @default.
• W2077587951 countsByYear W20775879512015 @default.
• W2077587951 countsByYear W20775879512016 @default.
• W2077587951 countsByYear W20775879512017 @default.
• W2077587951 countsByYear W20775879512018 @default.
• W2077587951 countsByYear W20775879512019 @default.
• W2077587951 countsByYear W20775879512020 @default.
• W2077587951 countsByYear W20775879512021 @default.
• W2077587951 countsByYear W20775879512022 @default.
• W2077587951 countsByYear W20775879512023 @default.
• W2077587951 crossrefType "journal-article" @default.
• W2077587951 hasAuthorship W2077587951A5000085125 @default.

• next