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- W2077596961 abstract "Nicotine, a secondary compound in tobacco, is not only addictive, but promotes angiogenesis, the formation of new blood vessels. Christopher Heescheen and colleagues [Nat. Med. (2001) 7, 833–839] used human cell lines and mouse model systems to show that nicotine enhances blood vessels in vitro and in vivo. Orally administered nicotine increases vascular growth in fibroblast cells in mice. The vessels are functional and allow blood to flow in them. Tobacco's siren song also stimulates tumor growth, nearly doubling lung tumor size after 16 days of exposure. The research team also observed that nicotine stimulates plaque formation, which depends on vascularization, in a mouse model of atherosclerosis. The molecular mechanism of nicotine angiogenesis remains to be determined. TS" @default.
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- W2077596961 date "2001-09-01" @default.
- W2077596961 modified "2023-09-24" @default.
- W2077596961 title "Nicotine's naughty bits" @default.
- W2077596961 doi "https://doi.org/10.1016/s1360-1385(01)02114-8" @default.
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