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• W2077598700 abstract "Abstract The quality control of mRNA maturation is a highly regulated process that surveys pre-mRNA integrity and eliminates improperly matured pre-mRNAs. In nature, certain viruses regulate the expression of their genes by hijacking the endogenous RNA quality control machinery. We demonstrate that the inclusion of 5′ splice sites within the 3′-untranslated region of a reporter gene in plants alters the pre-mRNA cleavage and polyadenylation process, resulting in pre-mRNA degradation, exemplifying a regulatory mechanism conserved between kingdoms. Altered pre-mRNA processing was associated with an inhibition of homologous gene expression in trans and the preferential accumulation of 24-nucleotide (nt) short-interfering RNAs (siRNAs) as opposed to 21-nt siRNA subspecies, suggesting that degradation of the aberrant pre-mRNA involves the silencing machinery. However, gene expression was not restored by coexpression of a silencing suppressor or in an RNA-dependent RNA polymerase (RDR6)-deficient background despite reduced 24-nt siRNA accumulation. Our data highlight a complex cross talk between the quality control RNA machinery, 3′-end pre-mRNA maturation, and RNA-silencing pathways capable of discriminating among different types of aberrant RNAs." @default.
• W2077598700 created "2016-06-24" @default.
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• W2077598700 date "2009-08-07" @default.
• W2077598700 modified "2023-10-14" @default.
• W2077598700 title "Ectopic 5′ Splice Sites Inhibit Gene Expression by Engaging RNA Surveillance and Silencing Pathways in Plants " @default.
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• W2077598700 doi "https://doi.org/10.1104/pp.109.139733" @default.
• W2077598700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2754638" @default.
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