Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077602960> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2077602960 endingPage "190" @default.
- W2077602960 startingPage "185" @default.
- W2077602960 abstract "In order to assess the potential of carbopol 974P-NF as matrix material in hydrophilic matrix tablets containing a slightly water-soluble drug, ibuprofen (IBF), controlled release matrix tablets of ibuprofen and carbopol 974P-NF, at different drug to polymer ratios, were prepared by the direct compression method. The influence of the concentration of the matrix material (carbopol 974P) and several co-excipients (lactose, microcrystalline cellulose, and starch) on the release rate of the drug was investigated. An in vitro dissolution test in pH 7.2 phosphate buffer solution showed that drug release from all the formulations containing carbopol 974P was considerably prolonged in concentration-dependent manners. Increasing the amount of carbopol 974P in tablets resulted in a reduction in the drug release rate and a linearization of the drug release curve. When the influence of the co-excipients on the release of the drug was examined, all of the co-excipients used in this study enhanced the release rate of IBF. However, lactose demonstrated slower and more linear release behavior as compared in microcrystalline cellulose or starch. The dissolution T50 and T90 values for the three co-excipients were in the order of lactose > microcrystalline cellulose > starch." @default.
- W2077602960 created "2016-06-24" @default.
- W2077602960 creator A5062179082 @default.
- W2077602960 creator A5090099469 @default.
- W2077602960 date "1998-07-01" @default.
- W2077602960 modified "2023-10-14" @default.
- W2077602960 title "Formulation and in vitro evaluation of ibuprofen-carbopol® 974P-NF controlled release matrix tablets III: influence of co-excipients on release rate of the drug" @default.
- W2077602960 cites W1965249610 @default.
- W2077602960 cites W1971476080 @default.
- W2077602960 cites W2025122753 @default.
- W2077602960 cites W2083306884 @default.
- W2077602960 cites W2083510973 @default.
- W2077602960 cites W2150225634 @default.
- W2077602960 doi "https://doi.org/10.1016/s0168-3659(97)00225-3" @default.
- W2077602960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9724905" @default.
- W2077602960 hasPublicationYear "1998" @default.
- W2077602960 type Work @default.
- W2077602960 sameAs 2077602960 @default.
- W2077602960 citedByCount "93" @default.
- W2077602960 countsByYear W20776029602012 @default.
- W2077602960 countsByYear W20776029602013 @default.
- W2077602960 countsByYear W20776029602014 @default.
- W2077602960 countsByYear W20776029602015 @default.
- W2077602960 countsByYear W20776029602016 @default.
- W2077602960 countsByYear W20776029602017 @default.
- W2077602960 countsByYear W20776029602018 @default.
- W2077602960 countsByYear W20776029602020 @default.
- W2077602960 countsByYear W20776029602021 @default.
- W2077602960 countsByYear W20776029602023 @default.
- W2077602960 crossrefType "journal-article" @default.
- W2077602960 hasAuthorship W2077602960A5062179082 @default.
- W2077602960 hasAuthorship W2077602960A5090099469 @default.
- W2077602960 hasConcept C106487976 @default.
- W2077602960 hasConcept C14029885 @default.
- W2077602960 hasConcept C163588942 @default.
- W2077602960 hasConcept C178790620 @default.
- W2077602960 hasConcept C185592680 @default.
- W2077602960 hasConcept C2777239854 @default.
- W2077602960 hasConcept C2778724459 @default.
- W2077602960 hasConcept C2779251873 @default.
- W2077602960 hasConcept C2779351475 @default.
- W2077602960 hasConcept C2779944601 @default.
- W2077602960 hasConcept C2781430271 @default.
- W2077602960 hasConcept C43617362 @default.
- W2077602960 hasConcept C529335014 @default.
- W2077602960 hasConcept C55493867 @default.
- W2077602960 hasConcept C71924100 @default.
- W2077602960 hasConcept C77281830 @default.
- W2077602960 hasConcept C88380143 @default.
- W2077602960 hasConcept C98274493 @default.
- W2077602960 hasConceptScore W2077602960C106487976 @default.
- W2077602960 hasConceptScore W2077602960C14029885 @default.
- W2077602960 hasConceptScore W2077602960C163588942 @default.
- W2077602960 hasConceptScore W2077602960C178790620 @default.
- W2077602960 hasConceptScore W2077602960C185592680 @default.
- W2077602960 hasConceptScore W2077602960C2777239854 @default.
- W2077602960 hasConceptScore W2077602960C2778724459 @default.
- W2077602960 hasConceptScore W2077602960C2779251873 @default.
- W2077602960 hasConceptScore W2077602960C2779351475 @default.
- W2077602960 hasConceptScore W2077602960C2779944601 @default.
- W2077602960 hasConceptScore W2077602960C2781430271 @default.
- W2077602960 hasConceptScore W2077602960C43617362 @default.
- W2077602960 hasConceptScore W2077602960C529335014 @default.
- W2077602960 hasConceptScore W2077602960C55493867 @default.
- W2077602960 hasConceptScore W2077602960C71924100 @default.
- W2077602960 hasConceptScore W2077602960C77281830 @default.
- W2077602960 hasConceptScore W2077602960C88380143 @default.
- W2077602960 hasConceptScore W2077602960C98274493 @default.
- W2077602960 hasIssue "2" @default.
- W2077602960 hasLocation W20776029601 @default.
- W2077602960 hasLocation W20776029602 @default.
- W2077602960 hasOpenAccess W2077602960 @default.
- W2077602960 hasPrimaryLocation W20776029601 @default.
- W2077602960 hasRelatedWork W1023883214 @default.
- W2077602960 hasRelatedWork W1967572886 @default.
- W2077602960 hasRelatedWork W1968102018 @default.
- W2077602960 hasRelatedWork W2005507233 @default.
- W2077602960 hasRelatedWork W2030643962 @default.
- W2077602960 hasRelatedWork W2033934392 @default.
- W2077602960 hasRelatedWork W3025637122 @default.
- W2077602960 hasRelatedWork W4309180724 @default.
- W2077602960 hasRelatedWork W2188741221 @default.
- W2077602960 hasRelatedWork W3093492364 @default.
- W2077602960 hasVolume "54" @default.
- W2077602960 isParatext "false" @default.
- W2077602960 isRetracted "false" @default.
- W2077602960 magId "2077602960" @default.
- W2077602960 workType "article" @default.