FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077604406> ?p ?o ?g. }

• W2077604406 endingPage "73" @default.
• W2077604406 startingPage "63" @default.
• W2077604406 abstract "Tumour necrosis factor (TNF) is involved in the pathogenesis of several diseases. In mice, human TNF signals only through p55, one of two murine TNF receptors. We here report a study of growth, viability and morphological alterations in transgenic mice expressing a low constitutive and tissue-restricted level of human TNF in vivo. The transgene was expressed solely in T cells. The transgenic mice showed a marked failure to thrive and a rapid cellular depletion in spleen and thymus. Slight fibrosis was seen in most tissues investigated, in addition to immature adipose tissue and irregular lymphocytic areas. Serum levels of hTNF were only slightly increased in the transgenic mice, enough, however, to cause an inflammatory reaction. All the symptoms were abrogated by an inhibitory hTNF antibody, demonstrating the essential role of hTNF in this phenotype. Transgenic mice constitute a multidimensional system allowing observation of disease processes over time in all tissues. The effects of hTNF were seen first and foremost in the lymphoid organs of the transgenic mice, verifying their cells as major targets at low levels of hTNF expression in the T-cell compartments. Chronic, low levels of TNF expression cause profound disturbances in lymphoid tissue development resulting in cachexia and premature death." @default.
• W2077604406 created "2016-06-24" @default.
• W2077604406 creator A5044374573 @default.
• W2077604406 creator A5090765289 @default.
• W2077604406 creator A5091250120 @default.
• W2077604406 date "2004-01-01" @default.
• W2077604406 modified "2023-10-17" @default.
• W2077604406 title "Involution of thymus and lymphoid depletion in mice expressing the hTNF transgene" @default.
• W2077604406 cites W1547412330 @default.
• W2077604406 cites W1722228043 @default.
• W2077604406 cites W1832527043 @default.
• W2077604406 cites W1965860042 @default.
• W2077604406 cites W1987595414 @default.
• W2077604406 cites W1997506405 @default.
• W2077604406 cites W1999246265 @default.
• W2077604406 cites W2009818179 @default.
• W2077604406 cites W2010298858 @default.
• W2077604406 cites W2010491773 @default.
• W2077604406 cites W2015032393 @default.
• W2077604406 cites W2015593526 @default.
• W2077604406 cites W2017720269 @default.
• W2077604406 cites W2029150849 @default.
• W2077604406 cites W2053101940 @default.
• W2077604406 cites W2067024450 @default.
• W2077604406 cites W2071682265 @default.
• W2077604406 cites W2072606138 @default.
• W2077604406 cites W2083726090 @default.
• W2077604406 cites W2084353045 @default.
• W2077604406 cites W2086255604 @default.
• W2077604406 cites W2106913223 @default.
• W2077604406 cites W2119543039 @default.
• W2077604406 cites W2119920165 @default.
• W2077604406 cites W2125220365 @default.
• W2077604406 cites W2126342903 @default.
• W2077604406 cites W2133071999 @default.
• W2077604406 cites W2135379366 @default.
• W2077604406 cites W2145591227 @default.
• W2077604406 cites W2151017891 @default.
• W2077604406 cites W2162465275 @default.
• W2077604406 cites W2253617528 @default.
• W2077604406 cites W4245119819 @default.
• W2077604406 cites W4253453819 @default.
• W2077604406 doi "https://doi.org/10.1111/j.1600-0463.2004.apm1120111.x" @default.
• W2077604406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14961977" @default.
• W2077604406 hasPublicationYear "2004" @default.
• W2077604406 type Work @default.
• W2077604406 sameAs 2077604406 @default.
• W2077604406 citedByCount "4" @default.
• W2077604406 countsByYear W20776044062019 @default.
• W2077604406 crossrefType "journal-article" @default.
• W2077604406 hasAuthorship W2077604406A5044374573 @default.
• W2077604406 hasAuthorship W2077604406A5090765289 @default.
• W2077604406 hasAuthorship W2077604406A5091250120 @default.
• W2077604406 hasConcept C102230213 @default.
• W2077604406 hasConcept C104317684 @default.
• W2077604406 hasConcept C126322002 @default.
• W2077604406 hasConcept C134018914 @default.
• W2077604406 hasConcept C141035611 @default.
• W2077604406 hasConcept C169760540 @default.
• W2077604406 hasConcept C171089720 @default.
• W2077604406 hasConcept C17991360 @default.
• W2077604406 hasConcept C181152851 @default.
• W2077604406 hasConcept C186720457 @default.
• W2077604406 hasConcept C203014093 @default.
• W2077604406 hasConcept C2776090121 @default.
• W2077604406 hasConcept C2777314012 @default.
• W2077604406 hasConcept C2778690821 @default.
• W2077604406 hasConcept C2780931953 @default.
• W2077604406 hasConcept C2781409172 @default.
• W2077604406 hasConcept C55493867 @default.
• W2077604406 hasConcept C71924100 @default.
• W2077604406 hasConcept C86803240 @default.
• W2077604406 hasConcept C8891405 @default.
• W2077604406 hasConceptScore W2077604406C102230213 @default.
• W2077604406 hasConceptScore W2077604406C104317684 @default.
• W2077604406 hasConceptScore W2077604406C126322002 @default.
• W2077604406 hasConceptScore W2077604406C134018914 @default.
• W2077604406 hasConceptScore W2077604406C141035611 @default.
• W2077604406 hasConceptScore W2077604406C169760540 @default.
• W2077604406 hasConceptScore W2077604406C171089720 @default.
• W2077604406 hasConceptScore W2077604406C17991360 @default.
• W2077604406 hasConceptScore W2077604406C181152851 @default.
• W2077604406 hasConceptScore W2077604406C186720457 @default.
• W2077604406 hasConceptScore W2077604406C203014093 @default.
• W2077604406 hasConceptScore W2077604406C2776090121 @default.
• W2077604406 hasConceptScore W2077604406C2777314012 @default.
• W2077604406 hasConceptScore W2077604406C2778690821 @default.
• W2077604406 hasConceptScore W2077604406C2780931953 @default.
• W2077604406 hasConceptScore W2077604406C2781409172 @default.
• W2077604406 hasConceptScore W2077604406C55493867 @default.
• W2077604406 hasConceptScore W2077604406C71924100 @default.
• W2077604406 hasConceptScore W2077604406C86803240 @default.
• W2077604406 hasConceptScore W2077604406C8891405 @default.
• W2077604406 hasIssue "1" @default.
• W2077604406 hasLocation W20776044061 @default.
• W2077604406 hasLocation W20776044062 @default.
• W2077604406 hasOpenAccess W2077604406 @default.
• W2077604406 hasPrimaryLocation W20776044061 @default.

• next