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- W2077607207 abstract "Carnitine acyltransferace (CAT), located on the mitochondrial inner membrane, catalyzes the reaction: This enzyme transfers acyl CoA units to the enzyme-rich matrix. The forward reaction (I), the pivotal rate-limiting step in fatty acid oxidation, occurs on the outer side of the membrane and is regulated by cytosolic malonyl CoA. The opposite reaction (II) has not been studied. After synthesizing 14C-acylcarnitine, we investigated the modification of this reaction (II) by numerous intramitochondrial metabolites. The normal CAT (prepared from rat liver) rate for this reaction (II) was 18±5 nmols/min/mg protein (mean ± S.E.; n = 7). Various CoA compounds, lactate, pyruvate, citrate and acetate did not affect this reaction at physiologic intramitochondrial concentrations (0.1 mM). However, the citric acid cycle intermediates fumarate, malate, and oxaloacetate were inhibitory (66 ± 9, 71 ± 8, 77 ± 8 percent of control, respectively; n = 7, p <,025). The attenuation of this reaction by these compounds may be salient to the overall regulation of hepatic ketogenesis, especially since glucagon alters the intracellular compartmentation of these metabolites." @default.
- W2077607207 created "2016-06-24" @default.
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- W2077607207 date "1985-04-01" @default.
- W2077607207 modified "2023-10-18" @default.
- W2077607207 title "1235 CARNITINE ACYLTRANSFERACE II: INHIBITION BY KREBS CYCLE INTERMEDIATES" @default.
- W2077607207 doi "https://doi.org/10.1203/00006450-198504000-01265" @default.
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