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• W2077609145 abstract "Plasminogen activation is a key event in the fibrinolytic system that results in the dissolution of blood clots, and also promotes cell migration and tissue remodelling. The recent structure determinations of microplasmin in complex with the bacterial plasminogen activators staphylokinase and streptokinase have provided novel insights into the molecular mechanisms of plasminogen activation and cofactor function. These bacterial proteins are cofactor molecules that contribute to exosite formation and enhance the substrate presentation to the enzyme. At the same time, they modulate the specificity of plasmin towards substrates and inhibitors, making a 'specificity switch' possible." @default.
• W2077609145 created "2016-06-24" @default.
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• W2077609145 date "2000-02-01" @default.
• W2077609145 modified "2023-10-13" @default.
• W2077609145 title "Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues" @default.
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• W2077609145 doi "https://doi.org/10.1016/s0968-0004(99)01521-2" @default.
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