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• W2077610106 abstract "Status epilepticus (SE) can result in acute neuronal injury with subsequent long-term age-dependent behavioral and histologic sequelae. To investigate potential mechanisms that may underlie SE-related neuronal injury, we studied the occurrence of programmed cell death (PCD) in the hippocampus in the kainic acid (KA) model.In adult rats, KA-induced SE resulted in DNA fragmentation documented at 30 h after KA injection. Ceramide, a known mediator of PCD in multiple neural and nonneural tissues, increased at 2-3 h after KA intraperitoneal injection, and then decreased to control levels before increasing again from 12 to 30 h after injection. MK801 pretreatment prevented KA-induced increases in ceramide levels and DNA fragmentation, whether there was reduction in seizure severity or not (achieved with 5 mg/kg and 1 mg/kg of MK801, respectively).Both ceramide increases and DNA fragmentation were observed after KA-induced SE in adult and in P35 rats. Ceramide did not increase after KA-induced SE in P7 pups, which also did not manifest any DNA fragmentation. Intrahippocampal injection of the active ceramide analogue C2-ceramide produced widespread DNA fragmentation, whereas the inactive ceramide analogue C2-dihydroceramide did not.Our data support the hypotheses that (a) N-methyl-d-aspartate-receptor activation results in ceramide increases and in DNA fragmentation; (b) ceramide is a mediator of PCD after SE; and (c) there are age-related differences in PCD and in the ceramide response after SE. Differences in the ceramide response could, potentially, be responsible for observed age-related differences in the response to SE." @default.
• W2077610106 created "2016-06-24" @default.
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• W2077610106 date "2003-03-01" @default.
• W2077610106 modified "2023-10-15" @default.
• W2077610106 title "Hippocampal Programmed Cell Death after Status Epilepticus: Evidence for NMDA-Receptor and Ceramide-Mediated Mechanisms" @default.
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• W2077610106 cites W1545053264 @default.
• W2077610106 cites W1788426598 @default.
• W2077610106 cites W1823104567 @default.
• W2077610106 cites W1874385193 @default.
• W2077610106 cites W1880554341 @default.
• W2077610106 cites W1971799685 @default.
• W2077610106 cites W1974832634 @default.
• W2077610106 cites W1981017578 @default.
• W2077610106 cites W1982157268 @default.
• W2077610106 cites W1986207229 @default.
• W2077610106 cites W1995355143 @default.
• W2077610106 cites W1995795887 @default.
• W2077610106 cites W1999888677 @default.
• W2077610106 cites W2001335888 @default.
• W2077610106 cites W2006754102 @default.
• W2077610106 cites W2008265157 @default.
• W2077610106 cites W2008754716 @default.
• W2077610106 cites W2010146496 @default.
• W2077610106 cites W2012854919 @default.
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• W2077610106 cites W2019836893 @default.
• W2077610106 cites W2023300694 @default.
• W2077610106 cites W2023840341 @default.
• W2077610106 cites W2030638243 @default.
• W2077610106 cites W2031937367 @default.
• W2077610106 cites W2036650593 @default.
• W2077610106 cites W2037707710 @default.
• W2077610106 cites W2043946447 @default.
• W2077610106 cites W2045649099 @default.
• W2077610106 cites W2046320735 @default.
• W2077610106 cites W2046562011 @default.
• W2077610106 cites W2049628205 @default.
• W2077610106 cites W2051336201 @default.
• W2077610106 cites W2052853635 @default.
• W2077610106 cites W2058080958 @default.
• W2077610106 cites W2061810763 @default.
• W2077610106 cites W2062246668 @default.
• W2077610106 cites W2063365220 @default.
• W2077610106 cites W2064210924 @default.
• W2077610106 cites W2065667920 @default.
• W2077610106 cites W2065766712 @default.
• W2077610106 cites W2068572725 @default.
• W2077610106 cites W2074780489 @default.
• W2077610106 cites W2077754511 @default.
• W2077610106 cites W2078623563 @default.
• W2077610106 cites W2080701565 @default.
• W2077610106 cites W2081919595 @default.
• W2077610106 cites W2086667758 @default.
• W2077610106 cites W2087496358 @default.
• W2077610106 cites W2088001693 @default.
• W2077610106 cites W2092639837 @default.
• W2077610106 cites W2096240982 @default.
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• W2077610106 cites W2115959438 @default.
• W2077610106 cites W2122334330 @default.
• W2077610106 cites W2126544407 @default.
• W2077610106 cites W2129041175 @default.
• W2077610106 cites W2136648921 @default.
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• W2077610106 doi "https://doi.org/10.1046/j.1528-1157.2003.22502.x" @default.
• W2077610106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12614382" @default.
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