FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077617784> ?p ?o ?g. }

• W2077617784 endingPage "e2660" @default.
• W2077617784 startingPage "e2660" @default.
• W2077617784 abstract "The occurrences of many environmentally-persistent and zoonotic infections are driven by ecosystem changes, which in turn are underpinned by land-use modifications that alter the governance of pathogen, biodiversity and human interactions. Our current understanding of these ecological changes on disease emergence however remains limited. Buruli ulcer is an emerging human skin disease caused by the mycobacterium, Mycobacterium ulcerans, for which the exact route of infection remains unclear. It can have a devastating impact on its human host, causing extensive necrosis of the skin and underlying tissue, often leading to permanent disability. The mycobacterium is associated with tropical aquatic environments and incidences of the disease are significantly higher on floodplains and where there is an increase of human aquatic activities. Although the disease has been previously diagnosed in South America, until now the presence of M. ulcerans DNA in the wild has only been identified in Australia where there have been significant outbreaks and in western and central regions of Africa where the disease is persistent. Here for the first time, we have identified the presence of the aetiological agent's DNA in environmental samples from South America. The DNA was positively identified using Real-time Polymerase Chain Reaction (PCR) on 163 environmental samples, taken from 23 freshwater bodies in French Guiana (Southern America), using primers for both IS2404 and for the ketoreductase-B domain of the M. ulcerans mycolactone polyketide synthase genes (KR). Five samples out of 163 were positive for both primers from three different water bodies. A further nine sites had low levels of IS2404 close to a standard CT of 35 and could potentially harbour M. ulcerans. The majority of our positive samples (8/14) came from filtered water. These results also reveal the Sinnamary River as a potential source of infection to humans." @default.
• W2077617784 created "2016-06-24" @default.
• W2077617784 creator A5003627411 @default.
• W2077617784 creator A5019102686 @default.
• W2077617784 creator A5034668726 @default.
• W2077617784 creator A5039430760 @default.
• W2077617784 creator A5042372398 @default.
• W2077617784 creator A5046905007 @default.
• W2077617784 creator A5053256357 @default.
• W2077617784 creator A5064499021 @default.
• W2077617784 creator A5083496550 @default.
• W2077617784 date "2014-01-30" @default.
• W2077617784 modified "2023-10-10" @default.
• W2077617784 title "First Detection of Mycobacterium ulcerans DNA in Environmental Samples from South America" @default.
• W2077617784 cites W1583956733 @default.
• W2077617784 cites W1827239630 @default.
• W2077617784 cites W1985559980 @default.
• W2077617784 cites W1992470594 @default.
• W2077617784 cites W2017551481 @default.
• W2077617784 cites W2058483543 @default.
• W2077617784 cites W2060352406 @default.
• W2077617784 cites W2068888509 @default.
• W2077617784 cites W2080356215 @default.
• W2077617784 cites W2098254741 @default.
• W2077617784 cites W2110196241 @default.
• W2077617784 cites W2110198965 @default.
• W2077617784 cites W2113555941 @default.
• W2077617784 cites W2118646800 @default.
• W2077617784 cites W2119591408 @default.
• W2077617784 cites W2123267129 @default.
• W2077617784 cites W2125564560 @default.
• W2077617784 cites W2144068113 @default.
• W2077617784 cites W2151809812 @default.
• W2077617784 cites W2171319103 @default.
• W2077617784 doi "https://doi.org/10.1371/journal.pntd.0002660" @default.
• W2077617784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3907311" @default.
• W2077617784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24498449" @default.
• W2077617784 hasPublicationYear "2014" @default.
• W2077617784 type Work @default.
• W2077617784 sameAs 2077617784 @default.
• W2077617784 citedByCount "29" @default.
• W2077617784 countsByYear W20776177842014 @default.
• W2077617784 countsByYear W20776177842015 @default.
• W2077617784 countsByYear W20776177842016 @default.
• W2077617784 countsByYear W20776177842017 @default.
• W2077617784 countsByYear W20776177842018 @default.
• W2077617784 countsByYear W20776177842019 @default.
• W2077617784 countsByYear W20776177842021 @default.
• W2077617784 countsByYear W20776177842022 @default.
• W2077617784 countsByYear W20776177842023 @default.
• W2077617784 crossrefType "journal-article" @default.
• W2077617784 hasAuthorship W2077617784A5003627411 @default.
• W2077617784 hasAuthorship W2077617784A5019102686 @default.
• W2077617784 hasAuthorship W2077617784A5034668726 @default.
• W2077617784 hasAuthorship W2077617784A5039430760 @default.
• W2077617784 hasAuthorship W2077617784A5042372398 @default.
• W2077617784 hasAuthorship W2077617784A5046905007 @default.
• W2077617784 hasAuthorship W2077617784A5053256357 @default.
• W2077617784 hasAuthorship W2077617784A5064499021 @default.
• W2077617784 hasAuthorship W2077617784A5083496550 @default.
• W2077617784 hasBestOaLocation W20776177841 @default.
• W2077617784 hasConcept C104317684 @default.
• W2077617784 hasConcept C116675565 @default.
• W2077617784 hasConcept C130217890 @default.
• W2077617784 hasConcept C142724271 @default.
• W2077617784 hasConcept C159047783 @default.
• W2077617784 hasConcept C18903297 @default.
• W2077617784 hasConcept C2776261420 @default.
• W2077617784 hasConcept C2777474118 @default.
• W2077617784 hasConcept C2779134260 @default.
• W2077617784 hasConcept C2779969263 @default.
• W2077617784 hasConcept C2780661791 @default.
• W2077617784 hasConcept C49105822 @default.
• W2077617784 hasConcept C54355233 @default.
• W2077617784 hasConcept C71924100 @default.
• W2077617784 hasConcept C86803240 @default.
• W2077617784 hasConcept C89423630 @default.
• W2077617784 hasConceptScore W2077617784C104317684 @default.
• W2077617784 hasConceptScore W2077617784C116675565 @default.
• W2077617784 hasConceptScore W2077617784C130217890 @default.
• W2077617784 hasConceptScore W2077617784C142724271 @default.
• W2077617784 hasConceptScore W2077617784C159047783 @default.
• W2077617784 hasConceptScore W2077617784C18903297 @default.
• W2077617784 hasConceptScore W2077617784C2776261420 @default.
• W2077617784 hasConceptScore W2077617784C2777474118 @default.
• W2077617784 hasConceptScore W2077617784C2779134260 @default.
• W2077617784 hasConceptScore W2077617784C2779969263 @default.
• W2077617784 hasConceptScore W2077617784C2780661791 @default.
• W2077617784 hasConceptScore W2077617784C49105822 @default.
• W2077617784 hasConceptScore W2077617784C54355233 @default.
• W2077617784 hasConceptScore W2077617784C71924100 @default.
• W2077617784 hasConceptScore W2077617784C86803240 @default.
• W2077617784 hasConceptScore W2077617784C89423630 @default.
• W2077617784 hasIssue "1" @default.
• W2077617784 hasLocation W20776177841 @default.
• W2077617784 hasLocation W20776177842 @default.
• W2077617784 hasLocation W20776177843 @default.
• W2077617784 hasLocation W20776177844 @default.

• next