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• W2077639673 abstract "Abstract Genes that interact or function together are often clustered in bacterial genomes, and it has been proposed that this clustering may affect gene expression. In this study, we directly compared gene expression in nonclustered arrangements and in three common clustered arrangements (codirectional, divergent, and operon) using synthetic circuits in Escherichia coli. We found that gene clustering had minimal effects on gene expression. Specifically, gene clustering did not alter constitutive expression levels or stochastic fluctuations in expression (“expression noise”). Remarkably, the expression of two genes that share the same chromosome position with the same promoter (operon) or with separate promoters (codirectional and divergent arrangements) was not significantly more correlated than genes at different chromosome positions (nonclustered arrangements). The only observed effect of clustering was increased transcription factor binding in codirectional and divergent gene arrangements due to DNA looping, but this is not a specific feature of clustering. In summary, we demonstrate that gene clustering is not a general modulator of gene expression, and therefore any effects of clustering are likely to occur only with specific genes or under certain conditions." @default.
• W2077639673 created "2016-06-24" @default.
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• W2077639673 date "2013-02-01" @default.
• W2077639673 modified "2023-09-26" @default.
• W2077639673 title "Minimal Effect of Gene Clustering on Expression in <i>Escherichia coli</i>" @default.
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• W2077639673 doi "https://doi.org/10.1534/genetics.112.147199" @default.
• W2077639673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3567736" @default.
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