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- W2077649619 abstract "Abstract: Parkinson's disease may be linked to defects in mitochondrial function. Mitochondrially transformed cells (cybrids) were created from Parkinson's disease patients or disease-free controls. Parkinson's disease cybrids had 26% less complex I activity, but maintained comparable basal calcium and energy levels. Parkinson's disease cybrids recovered from a carbachol-induced increase in cytosolic calcium 53% more slowly than controls even with lanthanum and thapsigargin blockade. Inhibition of complex I with the Parkinson's disease-inducing metabolite 1-methyl-4-phenylpyridinium (MPP+) similarly reduced the rate of recovery after carbachol. This MPP+-induced reduction in recovery rates was much more pronounced in control cybrids than in Parkinson's disease cybrids. Parkinson's disease cybrids had less carbonyl cyanide m-chlorophenylhydrazone-releasable calcium. Bypassing complex I with succinate partially restored Parkinson's disease cybrid, and MPP+ suppressed control cybrid recovery rates. The subtle alteration in calcium homeostasis of Parkinson's disease cybrids may reflect an increased susceptibility to cell death under circumstances not ordinarily toxic." @default.
- W2077649619 created "2016-06-24" @default.
- W2077649619 creator A5001023467 @default.
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- W2077649619 date "2002-11-18" @default.
- W2077649619 modified "2023-10-14" @default.
- W2077649619 title "Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson's Disease" @default.
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- W2077649619 cites W1512984914 @default.
- W2077649619 cites W1586753603 @default.
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- W2077649619 cites W1605378381 @default.
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- W2077649619 cites W1910407513 @default.
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- W2077649619 cites W1972925133 @default.
- W2077649619 cites W1975551314 @default.
- W2077649619 cites W1978912987 @default.
- W2077649619 cites W1983178060 @default.
- W2077649619 cites W1987276980 @default.
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- W2077649619 cites W1996568613 @default.
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- W2077649619 cites W2046016490 @default.
- W2077649619 cites W2051493425 @default.
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- W2077649619 cites W2063501717 @default.
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- W2077649619 cites W2069174611 @default.
- W2077649619 cites W2069642809 @default.
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- W2077649619 cites W2077260129 @default.
- W2077649619 cites W2077476788 @default.
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- W2077649619 cites W2084826163 @default.
- W2077649619 cites W2087077651 @default.
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- W2077649619 cites W2093351124 @default.
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- W2077649619 cites W2134478550 @default.
- W2077649619 cites W2136372119 @default.
- W2077649619 cites W2140563138 @default.
- W2077649619 cites W2141260882 @default.
- W2077649619 cites W2146502895 @default.
- W2077649619 cites W2150200455 @default.
- W2077649619 cites W2154540873 @default.
- W2077649619 cites W2155395884 @default.
- W2077649619 cites W2160690724 @default.
- W2077649619 cites W2161946158 @default.
- W2077649619 cites W2166930817 @default.
- W2077649619 cites W2170506039 @default.
- W2077649619 cites W2197521137 @default.
- W2077649619 cites W2396470512 @default.
- W2077649619 cites W2410355805 @default.
- W2077649619 cites W2412757935 @default.
- W2077649619 cites W3087765763 @default.
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- W2077649619 doi "https://doi.org/10.1046/j.1471-4159.1997.68031221.x" @default.
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