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- W2077656589 abstract "Abstract Enteric glial cells (EGCs) represent an extensive but relatively poorly described cell population within the gastrointestinal tract. Accumulating data suggest that EGCs represent the morphological and functional equivalent of CNS astrocytes within the enteric nervous system (ENS). The EGC network has trophic and protective functions toward enteric neurons and is fully implicated in the integration and the modulation of neuronal activities. Moreover, EGCs seem to be active elements of the ENS during intestinal inflammatory and immune responses, sharing with astrocytes the ability to act as antigen‐presenting cells and interacting with the mucosal immune system via the expression of cytokines and cytokine receptors. Transgenic mouse systems have demonstrated that specific ablation of EGC by chemical ablation or autoimmune T‐cell targeting induces an intestinal pathology that shows similarities to the early intestinal immunopathology of Crohn's disease. EGCs may also share with astrocytes the ability to regulate tissue integrity, thereby postulating that similar interactions to those observed for the blood‐brain barrier may also be partly responsible for regulating mucosal and vascular permeability in the gastrointestinal tract. Disruption of the EGC network in Crohn's disease patients may represent one possible cause for the enhanced mucosal permeability state and vascular dysfunction that are thought to favor mucosal inflammation. GLIA 41:81–93, 2003. © 2003 Wiley‐Liss, Inc." @default.
- W2077656589 created "2016-06-24" @default.
- W2077656589 creator A5009191488 @default.
- W2077656589 creator A5027483078 @default.
- W2077656589 creator A5044356368 @default.
- W2077656589 date "2002-11-26" @default.
- W2077656589 modified "2023-10-17" @default.
- W2077656589 title "Role of enteric glial cells in inflammatory bowel disease" @default.
- W2077656589 cites W1491527820 @default.
- W2077656589 cites W1495439714 @default.
- W2077656589 cites W1528518138 @default.
- W2077656589 cites W1580853286 @default.
- W2077656589 cites W1606934029 @default.
- W2077656589 cites W1626734299 @default.
- W2077656589 cites W1642457845 @default.
- W2077656589 cites W1670573097 @default.
- W2077656589 cites W1864765563 @default.
- W2077656589 cites W1894334234 @default.
- W2077656589 cites W1909691032 @default.
- W2077656589 cites W1942398216 @default.
- W2077656589 cites W1964743056 @default.
- W2077656589 cites W1965356195 @default.
- W2077656589 cites W1965410604 @default.
- W2077656589 cites W1967156795 @default.
- W2077656589 cites W1967825344 @default.
- W2077656589 cites W1968788238 @default.
- W2077656589 cites W1969619562 @default.
- W2077656589 cites W1971238657 @default.
- W2077656589 cites W1974019237 @default.
- W2077656589 cites W1974693938 @default.
- W2077656589 cites W1975422958 @default.
- W2077656589 cites W1976572358 @default.
- W2077656589 cites W1978748245 @default.
- W2077656589 cites W1981135758 @default.
- W2077656589 cites W1981514060 @default.
- W2077656589 cites W1985323653 @default.
- W2077656589 cites W1986488143 @default.
- W2077656589 cites W1987495556 @default.
- W2077656589 cites W1989927249 @default.
- W2077656589 cites W1993188746 @default.
- W2077656589 cites W1993272169 @default.
- W2077656589 cites W1995565380 @default.
- W2077656589 cites W1996574408 @default.
- W2077656589 cites W1996719432 @default.
- W2077656589 cites W1998047506 @default.
- W2077656589 cites W2000208875 @default.
- W2077656589 cites W2000441131 @default.
- W2077656589 cites W2000997159 @default.
- W2077656589 cites W2001741486 @default.
- W2077656589 cites W2002707914 @default.
- W2077656589 cites W2006289803 @default.
- W2077656589 cites W2006862861 @default.
- W2077656589 cites W2007465397 @default.
- W2077656589 cites W2008752643 @default.
- W2077656589 cites W2011285612 @default.
- W2077656589 cites W2012330659 @default.
- W2077656589 cites W2016618675 @default.
- W2077656589 cites W2019856386 @default.
- W2077656589 cites W2023713829 @default.
- W2077656589 cites W2024400996 @default.
- W2077656589 cites W2025134252 @default.
- W2077656589 cites W2027586189 @default.
- W2077656589 cites W2028358869 @default.
- W2077656589 cites W2030447048 @default.
- W2077656589 cites W2032123628 @default.
- W2077656589 cites W2032984191 @default.
- W2077656589 cites W2033939933 @default.
- W2077656589 cites W2034466207 @default.
- W2077656589 cites W2035664677 @default.
- W2077656589 cites W2041035653 @default.
- W2077656589 cites W2043985651 @default.
- W2077656589 cites W2046984200 @default.
- W2077656589 cites W2047638488 @default.
- W2077656589 cites W2051601661 @default.
- W2077656589 cites W2051947267 @default.
- W2077656589 cites W2052343130 @default.
- W2077656589 cites W2063063986 @default.
- W2077656589 cites W2065387581 @default.
- W2077656589 cites W2068838941 @default.
- W2077656589 cites W2069691555 @default.
- W2077656589 cites W2069996507 @default.
- W2077656589 cites W2070665570 @default.
- W2077656589 cites W2070887098 @default.
- W2077656589 cites W2077683978 @default.
- W2077656589 cites W2078533888 @default.
- W2077656589 cites W2082062343 @default.
- W2077656589 cites W2083723288 @default.
- W2077656589 cites W2084654578 @default.
- W2077656589 cites W2085106063 @default.
- W2077656589 cites W2086689283 @default.
- W2077656589 cites W2089319499 @default.
- W2077656589 cites W2089348287 @default.
- W2077656589 cites W2092723076 @default.
- W2077656589 cites W2110985473 @default.
- W2077656589 cites W2113855055 @default.
- W2077656589 cites W2115609883 @default.
- W2077656589 cites W2115810166 @default.
- W2077656589 cites W2122678204 @default.