FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077662448> ?p ?o ?g. }

• W2077662448 abstract "A number of biomechanical properties of various types of pili expressed by Escherichia coli, predominantly their force-versus-elongation behavior, have previously been assessed in detail on a single pilus level. In vivo, however, bacteria bind in general to host cells by a multitude of pili, which presumably provides them with adhesion properties that differs from those of single pili. Based upon the previously assessed biomechanical properties of individual pili, this work presents a theoretical analysis of the adhesion properties of multipili-attaching bacteria expressing helixlike pili exposed to an external force. Expressions for the adhesion lifetime of dual- and multipili-attaching bacteria are derived and their validity is verified by Monte Carlo simulations. It is demonstrated that the adhesion lifetime of a multipili-binding bacterium depends to a large degree on the cooperativity of the attaching pili, which, in turn, depends strongly on their internal biomechanical properties, in particular their helixlike structure and its ability to elongate, which, in turn, depends on the intrinsic properties of the bonds, e.g., their lengths and activation energies. It is shown, for example, that a decrease in the length of a layer-to-layer bond in the rod of P pili, expressed by E. coli, by 50% leads to a decrease in the adhesion lifetime of a bacterium attaching by ten pili and exposed to a force of 500 pN by three orders of magnitude. The results indicate moreover that the intrinsic properties of the rod for this particular type of pili are optimized for multipili attachment under a broad range of external forces and presumably also to its in vivo environment. For example, P pili seems to be optimized to withstand a force exposure during approximately 3 s, which correspond to the time it takes for a bolus to pass a bacterium attached to the ureteral wall. Even though the results presented in this work apply quantitatively to one type of pilus, they are assumed to apply qualitatively to all helixlike pili systems expressing slip bonds." @default.
• W2077662448 created "2016-06-24" @default.
• W2077662448 creator A5000467832 @default.
• W2077662448 creator A5072992808 @default.
• W2077662448 date "2009-06-17" @default.
• W2077662448 modified "2023-09-23" @default.
• W2077662448 title "Multipili attachment of bacteria with helixlike pili exposed to stress" @default.
• W2077662448 cites W1967384112 @default.
• W2077662448 cites W1987324725 @default.
• W2077662448 cites W1991610185 @default.
• W2077662448 cites W1992285721 @default.
• W2077662448 cites W1997999034 @default.
• W2077662448 cites W1998798312 @default.
• W2077662448 cites W2001781015 @default.
• W2077662448 cites W2012192017 @default.
• W2077662448 cites W2019877102 @default.
• W2077662448 cites W2021210686 @default.
• W2077662448 cites W2022178880 @default.
• W2077662448 cites W2022403497 @default.
• W2077662448 cites W2036083275 @default.
• W2077662448 cites W2037438396 @default.
• W2077662448 cites W2039817895 @default.
• W2077662448 cites W2044545453 @default.
• W2077662448 cites W2052192720 @default.
• W2077662448 cites W2053572808 @default.
• W2077662448 cites W2056673837 @default.
• W2077662448 cites W2061884954 @default.
• W2077662448 cites W2062818612 @default.
• W2077662448 cites W2065495830 @default.
• W2077662448 cites W2070639142 @default.
• W2077662448 cites W2074728845 @default.
• W2077662448 cites W2094448747 @default.
• W2077662448 cites W2097535676 @default.
• W2077662448 cites W2097750123 @default.
• W2077662448 cites W2111579872 @default.
• W2077662448 cites W2121956307 @default.
• W2077662448 cites W2125813323 @default.
• W2077662448 cites W2129491316 @default.
• W2077662448 cites W2145105787 @default.
• W2077662448 cites W2152607628 @default.
• W2077662448 doi "https://doi.org/10.1063/1.3148027" @default.
• W2077662448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19548763" @default.
• W2077662448 hasPublicationYear "2009" @default.
• W2077662448 type Work @default.
• W2077662448 sameAs 2077662448 @default.
• W2077662448 citedByCount "17" @default.
• W2077662448 countsByYear W20776624482012 @default.
• W2077662448 countsByYear W20776624482013 @default.
• W2077662448 countsByYear W20776624482014 @default.
• W2077662448 countsByYear W20776624482016 @default.
• W2077662448 countsByYear W20776624482018 @default.
• W2077662448 countsByYear W20776624482020 @default.
• W2077662448 countsByYear W20776624482022 @default.
• W2077662448 crossrefType "journal-article" @default.
• W2077662448 hasAuthorship W2077662448A5000467832 @default.
• W2077662448 hasAuthorship W2077662448A5072992808 @default.
• W2077662448 hasConcept C104317684 @default.
• W2077662448 hasConcept C12554922 @default.
• W2077662448 hasConcept C166014724 @default.
• W2077662448 hasConcept C174832134 @default.
• W2077662448 hasConcept C178790620 @default.
• W2077662448 hasConcept C185592680 @default.
• W2077662448 hasConcept C39103817 @default.
• W2077662448 hasConcept C523546767 @default.
• W2077662448 hasConcept C54355233 @default.
• W2077662448 hasConcept C547475151 @default.
• W2077662448 hasConcept C55493867 @default.
• W2077662448 hasConcept C58123911 @default.
• W2077662448 hasConcept C8010536 @default.
• W2077662448 hasConcept C84416704 @default.
• W2077662448 hasConcept C86803240 @default.
• W2077662448 hasConceptScore W2077662448C104317684 @default.
• W2077662448 hasConceptScore W2077662448C12554922 @default.
• W2077662448 hasConceptScore W2077662448C166014724 @default.
• W2077662448 hasConceptScore W2077662448C174832134 @default.
• W2077662448 hasConceptScore W2077662448C178790620 @default.
• W2077662448 hasConceptScore W2077662448C185592680 @default.
• W2077662448 hasConceptScore W2077662448C39103817 @default.
• W2077662448 hasConceptScore W2077662448C523546767 @default.
• W2077662448 hasConceptScore W2077662448C54355233 @default.
• W2077662448 hasConceptScore W2077662448C547475151 @default.
• W2077662448 hasConceptScore W2077662448C55493867 @default.
• W2077662448 hasConceptScore W2077662448C58123911 @default.
• W2077662448 hasConceptScore W2077662448C8010536 @default.
• W2077662448 hasConceptScore W2077662448C84416704 @default.
• W2077662448 hasConceptScore W2077662448C86803240 @default.
• W2077662448 hasIssue "23" @default.
• W2077662448 hasLocation W20776624481 @default.
• W2077662448 hasLocation W20776624482 @default.
• W2077662448 hasOpenAccess W2077662448 @default.
• W2077662448 hasPrimaryLocation W20776624481 @default.
• W2077662448 hasRelatedWork W2007839979 @default.
• W2077662448 hasRelatedWork W2043966332 @default.
• W2077662448 hasRelatedWork W2077662448 @default.
• W2077662448 hasRelatedWork W2100283500 @default.
• W2077662448 hasRelatedWork W2119633818 @default.
• W2077662448 hasRelatedWork W2140396153 @default.
• W2077662448 hasRelatedWork W2314962732 @default.
• W2077662448 hasRelatedWork W2356742960 @default.
• W2077662448 hasRelatedWork W2565357520 @default.

• next