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- W2077663013 abstract "Epoetin alfa is an established and effective treatment for anemia in dialysis patients. Current available preparations in the United States include Epoetin and Darbepoetin alfa. Recently, our Formulary Committee deemed both products therapeutically equivalent, and chose Darbepoetin as the sole erythropoiesis stimulation agent. To evaluate the impact of this change we initiated a prospective longitudinal observational study of 54 patients (mean age: 61±16 years; 47% female; 30%; black). Median values for the quarter preceding the date of change (PRE) were compared to those from the subsequent three months starting 30 days after conversion (POST). Epoetin was administered intravenously thrice weekly and Darbepoetin once weekly. Results are expressed as mean ± SEM. The median Epoetin dose during the PRE period was 12,000 U/week. The conversion to darbepoetin alfa was done following the manufacture’s recommendation. However, dosages had to be ramped up because hemoglobin values fell 7%. The median dose for the POST period was 60 mcg vs. the package insert suggestion of 40 mcg per week. In conclusion, this study suggests that conversion to intravenous Darbepoetin should be calculated as 1 mcg per 200 U of Epoetin.Table" @default.
- W2077663013 created "2016-06-24" @default.
- W2077663013 creator A5023828112 @default.
- W2077663013 date "2006-03-01" @default.
- W2077663013 modified "2023-09-26" @default.
- W2077663013 title "HEMOGLOBIN CONCENTRATION CHANGES AFTER CONVERTING FROM EPOETIN TO DARBEPOETIN ALFA IN A CLINICAL PRACTICE SETTING" @default.
- W2077663013 doi "https://doi.org/10.1097/00002480-200603000-00318" @default.
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