FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077665086> ?p ?o ?g. }

• W2077665086 endingPage "650" @default.
• W2077665086 startingPage "641" @default.
• W2077665086 abstract "Diminished left frontotemporal connectivity is among the most frequently reported findings in schizophrenia and there is evidence that altered neuronal myelination may in part account for this deficit. Several investigations have suggested that variations of the genes that encode the Neuregulin 1 (NRG1)-ErbB4 receptor complex are associated with schizophrenia illness. As NRG1--ErbB4 has been implicated in neuronal myelination, we investigated with diffusion tensor imaging (DTI) whether fractional anisotropy (FA)--a putative measure of neuronal myelination--is predicted by a risk haplotype of the ErbB4 gene. The effects of the ErbB4 genotype were investigated in healthy subjects (N=59; mean age: 22.6+/-1.8 years). We also measured reaction time (RT) during a selective attention/working memory paradigm (visual oddball). In the schizophrenia risk genotype group, we found lower FA in the temporal lobe white matter (WM) including frontotemporal fiber tracts, predominantly in the left hemisphere. RT was increased in the risk genotype group and correlated with FA in the affected brain region. As FA is considered to index structural integrity of WM, to which neuronal fiber myelination is contributing, our results suggest that variations of the ErbB4 genotype may confer risk for schizophrenia illness via its impact on left frontotemporal connectivity in human brain. Reliability and validity of the result is suggested by our observation that (1) the FA-genotype association was not only obtained in the entire sample but also in both the split halves and (2) a statistical relationship was found among RT, genotype and FA." @default.
• W2077665086 created "2016-06-24" @default.
• W2077665086 creator A5032531763 @default.
• W2077665086 creator A5034682876 @default.
• W2077665086 creator A5042245601 @default.
• W2077665086 creator A5052945107 @default.
• W2077665086 creator A5085024791 @default.
• W2077665086 creator A5088083613 @default.
• W2077665086 date "2008-07-30" @default.
• W2077665086 modified "2023-09-30" @default.
• W2077665086 title "ErbB4 Genotype Predicts Left Frontotemporal Structural Connectivity in Human Brain" @default.
• W2077665086 cites W1505963533 @default.
• W2077665086 cites W1966083344 @default.
• W2077665086 cites W1970995631 @default.
• W2077665086 cites W1977421564 @default.
• W2077665086 cites W1980122382 @default.
• W2077665086 cites W1981340850 @default.
• W2077665086 cites W1997602948 @default.
• W2077665086 cites W2010993988 @default.
• W2077665086 cites W2016717347 @default.
• W2077665086 cites W2016997563 @default.
• W2077665086 cites W2023368138 @default.
• W2077665086 cites W2025008591 @default.
• W2077665086 cites W2031155687 @default.
• W2077665086 cites W2033165739 @default.
• W2077665086 cites W2038661578 @default.
• W2077665086 cites W2039181569 @default.
• W2077665086 cites W2039576727 @default.
• W2077665086 cites W2041862491 @default.
• W2077665086 cites W2048181659 @default.
• W2077665086 cites W2049973822 @default.
• W2077665086 cites W2050468619 @default.
• W2077665086 cites W2067710230 @default.
• W2077665086 cites W2069673779 @default.
• W2077665086 cites W2071090720 @default.
• W2077665086 cites W2082562090 @default.
• W2077665086 cites W2086114072 @default.
• W2077665086 cites W2089127919 @default.
• W2077665086 cites W2092250372 @default.
• W2077665086 cites W2093809331 @default.
• W2077665086 cites W2097333356 @default.
• W2077665086 cites W2105097410 @default.
• W2077665086 cites W2106533387 @default.
• W2077665086 cites W2107616280 @default.
• W2077665086 cites W2116774419 @default.
• W2077665086 cites W2119848633 @default.
• W2077665086 cites W2122606472 @default.
• W2077665086 cites W2131192891 @default.
• W2077665086 cites W2135198700 @default.
• W2077665086 cites W2140035683 @default.
• W2077665086 cites W2141245108 @default.
• W2077665086 cites W2142269585 @default.
• W2077665086 cites W2150667092 @default.
• W2077665086 cites W2152559989 @default.
• W2077665086 cites W2156145226 @default.
• W2077665086 cites W2161820433 @default.
• W2077665086 cites W2162530578 @default.
• W2077665086 cites W2166203834 @default.
• W2077665086 cites W2313322632 @default.
• W2077665086 doi "https://doi.org/10.1038/npp.2008.112" @default.
• W2077665086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18668031" @default.
• W2077665086 hasPublicationYear "2008" @default.
• W2077665086 type Work @default.
• W2077665086 sameAs 2077665086 @default.
• W2077665086 citedByCount "68" @default.
• W2077665086 countsByYear W20776650862012 @default.
• W2077665086 countsByYear W20776650862013 @default.
• W2077665086 countsByYear W20776650862014 @default.
• W2077665086 countsByYear W20776650862015 @default.
• W2077665086 countsByYear W20776650862017 @default.
• W2077665086 countsByYear W20776650862019 @default.
• W2077665086 countsByYear W20776650862020 @default.
• W2077665086 countsByYear W20776650862021 @default.
• W2077665086 countsByYear W20776650862023 @default.
• W2077665086 crossrefType "journal-article" @default.
• W2077665086 hasAuthorship W2077665086A5032531763 @default.
• W2077665086 hasAuthorship W2077665086A5034682876 @default.
• W2077665086 hasAuthorship W2077665086A5042245601 @default.
• W2077665086 hasAuthorship W2077665086A5052945107 @default.
• W2077665086 hasAuthorship W2077665086A5085024791 @default.
• W2077665086 hasAuthorship W2077665086A5088083613 @default.
• W2077665086 hasBestOaLocation W20776650861 @default.
• W2077665086 hasConcept C101544691 @default.
• W2077665086 hasConcept C104317684 @default.
• W2077665086 hasConcept C118552586 @default.
• W2077665086 hasConcept C126322002 @default.
• W2077665086 hasConcept C126838900 @default.
• W2077665086 hasConcept C135763542 @default.
• W2077665086 hasConcept C143409427 @default.
• W2077665086 hasConcept C15744967 @default.
• W2077665086 hasConcept C169760540 @default.
• W2077665086 hasConcept C170493617 @default.
• W2077665086 hasConcept C2776412080 @default.
• W2077665086 hasConcept C2776939681 @default.
• W2077665086 hasConcept C2778186239 @default.
• W2077665086 hasConcept C2778641062 @default.
• W2077665086 hasConcept C2779134260 @default.
• W2077665086 hasConcept C2779483572 @default.

• next