FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077665601> ?p ?o ?g. }

• W2077665601 endingPage "343" @default.
• W2077665601 startingPage "335" @default.
• W2077665601 abstract "Background: The treatment of bulky recurrent melanotic lesions of extremities with isolated limb perfusion with high dose chemotherapy offers palliation in a number of patients. However, the question is raised whether these major surgical procedures are too risky to warrant performing them in elderly patients. Methods: Sixty-seven limbs were perfused in 60 patients with various drugs from 1976 through 1996 (35, imidazole carboxamide; 7, cisplatin; 20, carboplatin; 5, thiotepa). Among the 67 perfusions, 20 were in patients aged 70 years and older. Perfusion was performed for 16 upper extremities and 51 lower extremities by using the pump oxygenator for 1 hour. Results: A total of 19 complications were noted after a total of 14 of the 67 perfusions (21%) (postoperative edema, 5; seroma, 4; wound separation or infection, 9; nonfatal pulmonary embolus, 1). The complications in 4 of 20 perfusions in the older patients (20%) were less than in 15 of 47 perfusions in the younger patients (32%). Among the 17 patients older than 70 years of age who were treated with perfusions for recurrent disease, four patients (24%) are alive with no evidence of disease (NED) for a median of 29 months (range, 16 to 80 months); one patient is now more than 6 years with NED after her third perfusion for repeated in-transit disease. Another 2 of 17 patients (12%) are alive with disease for a median of 89 months (range, 54 to 123 mos). The remaining 11 patients (64%) are dead of their disease. These data are comparable to the control rates in the group of younger patients in the study. Overall, half of all the patients (14 of 28) who died of their disease in both groups had maintained local control of their involved extremities. Conclusions: Aggressive treatment in selected patients with regional isolated perfusion of limbs for melanoma can lead to significant palliation of symptoms and salvage of limbs with adequate disease-free control and occasional survival benefit. This series of patients was associated with meaningful disease control and with few serious complications. Perfusions are tolerated well by patients in their 70s and 80s; therefore advanced age is not a contraindication to this procedure in carefully selected patients. (Surgery 1998;123:335-43.)" @default.
• W2077665601 created "2016-06-24" @default.
• W2077665601 creator A5001993547 @default.
• W2077665601 creator A5041145888 @default.
• W2077665601 date "1998-03-01" @default.
• W2077665601 modified "2023-09-24" @default.
• W2077665601 title "Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients" @default.
• W2077665601 cites W1889451488 @default.
• W2077665601 cites W1964131973 @default.
• W2077665601 cites W1970106709 @default.
• W2077665601 cites W1986892808 @default.
• W2077665601 cites W1994586074 @default.
• W2077665601 cites W2006819398 @default.
• W2077665601 cites W2033005592 @default.
• W2077665601 cites W2033452192 @default.
• W2077665601 cites W2037062806 @default.
• W2077665601 cites W2043823345 @default.
• W2077665601 cites W2045565618 @default.
• W2077665601 cites W2051103642 @default.
• W2077665601 cites W2053899537 @default.
• W2077665601 cites W2056519289 @default.
• W2077665601 cites W2059159193 @default.
• W2077665601 cites W2083675378 @default.
• W2077665601 cites W2145667987 @default.
• W2077665601 cites W2155225530 @default.
• W2077665601 cites W2334586393 @default.
• W2077665601 cites W2397130603 @default.
• W2077665601 cites W2400918748 @default.
• W2077665601 cites W2405563092 @default.
• W2077665601 cites W2410821361 @default.
• W2077665601 cites W2461409539 @default.
• W2077665601 cites W2485373561 @default.
• W2077665601 doi "https://doi.org/10.1016/s0039-6060(98)70188-6" @default.
• W2077665601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9526527" @default.
• W2077665601 hasPublicationYear "1998" @default.
• W2077665601 type Work @default.
• W2077665601 sameAs 2077665601 @default.
• W2077665601 citedByCount "4" @default.
• W2077665601 crossrefType "journal-article" @default.
• W2077665601 hasAuthorship W2077665601A5001993547 @default.
• W2077665601 hasAuthorship W2077665601A5041145888 @default.
• W2077665601 hasBestOaLocation W20776656011 @default.
• W2077665601 hasConcept C126322002 @default.
• W2077665601 hasConcept C141071460 @default.
• W2077665601 hasConcept C146957229 @default.
• W2077665601 hasConcept C2776694085 @default.
• W2077665601 hasConcept C2776755627 @default.
• W2077665601 hasConcept C2779409168 @default.
• W2077665601 hasConcept C2779968505 @default.
• W2077665601 hasConcept C42219234 @default.
• W2077665601 hasConcept C71924100 @default.
• W2077665601 hasConcept C81182388 @default.
• W2077665601 hasConceptScore W2077665601C126322002 @default.
• W2077665601 hasConceptScore W2077665601C141071460 @default.
• W2077665601 hasConceptScore W2077665601C146957229 @default.
• W2077665601 hasConceptScore W2077665601C2776694085 @default.
• W2077665601 hasConceptScore W2077665601C2776755627 @default.
• W2077665601 hasConceptScore W2077665601C2779409168 @default.
• W2077665601 hasConceptScore W2077665601C2779968505 @default.
• W2077665601 hasConceptScore W2077665601C42219234 @default.
• W2077665601 hasConceptScore W2077665601C71924100 @default.
• W2077665601 hasConceptScore W2077665601C81182388 @default.
• W2077665601 hasIssue "3" @default.
• W2077665601 hasLocation W20776656011 @default.
• W2077665601 hasLocation W20776656012 @default.
• W2077665601 hasOpenAccess W2077665601 @default.
• W2077665601 hasPrimaryLocation W20776656011 @default.
• W2077665601 hasRelatedWork W2003938723 @default.
• W2077665601 hasRelatedWork W2022952477 @default.
• W2077665601 hasRelatedWork W2027313211 @default.
• W2077665601 hasRelatedWork W2064428643 @default.
• W2077665601 hasRelatedWork W2118496982 @default.
• W2077665601 hasRelatedWork W2439875401 @default.
• W2077665601 hasRelatedWork W2943097693 @default.
• W2077665601 hasRelatedWork W3164099605 @default.
• W2077665601 hasRelatedWork W4235734420 @default.
• W2077665601 hasRelatedWork W4305082178 @default.
• W2077665601 hasVolume "123" @default.
• W2077665601 isParatext "false" @default.
• W2077665601 isRetracted "false" @default.
• W2077665601 magId "2077665601" @default.
• W2077665601 workType "article" @default.