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• W2077669090 abstract "Th17 cells are a subset of T cells that play crucial roles in the pathogenesis of many inflammatory diseases. We report here the identification of IKKα (inhibitor of NF-κB kinase-α) as a key transcriptional regulator of the Th17 lineage. T cells expressing a nonactivatable form of IKKα were significantly compromised in their ability to produce IL-17 and to initiate neural inflammation. IKKα is present in the nuclei of resting CD4+ T cells. Upon Th17 differentiation, IKKα selectively associated with the Il17a locus, and promoted its histone H3 phosphorylation and transcriptional activation in a NF-κB–independent manner. These findings indicate that nuclear IKKα maintains the Th17 phenotype by activating the Il17a gene." @default.
• W2077669090 created "2016-06-24" @default.
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• W2077669090 date "2011-03-14" @default.
• W2077669090 modified "2023-10-06" @default.
• W2077669090 title "Transcriptional regulation of the Th17 immune response by IKKα" @default.
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• W2077669090 doi "https://doi.org/10.1084/jem.20091346" @default.
• W2077669090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3135338" @default.
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