FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077672218> ?p ?o ?g. }

• W2077672218 endingPage "1373" @default.
• W2077672218 startingPage "1361" @default.
• W2077672218 abstract "In inflammation, the responses to noxious stimuli are controlled by the highly modulated interactions between various immune cells and chemical mediators. The purpose of this study is to evaluate and compare the anti-inflammatory effect of diterpenoids isolated from Andrographis paniculata, including dehydroandrographolide (AP1), andrographolide (AP2) and neoandrographolide (AP3), on the production of inflammatory cytokines and COX activities. Furthermore, the alteration of gene expression involved in this activity was investigated in the most potent compound to elucidate the other possible molecular mechanisms. AP1 (30.1 μM; 10 μg/ml) and AP2 (28.5 μM; 10 μg/ml) markedly inhibited COX-1 in ionophore A23187-induced human platelets. AP2 (28.5 μM) and AP3 (20.8 μM; 10 μg/ml) strongly suppressed the LPS-stimulated COX-2 activity in human blood. In addition, AP2 modulated the level of LPS-induced TNF-α, IL-6, IL-1β and IL-10 secretion in human blood in a concentration-dependent manner. The results revealed that AP2 exhibited the highest efficacy. Therefore, changes in the levels of mRNA transcripts by AP2 were further measured using human cDNA microarrays. The molecular response to AP2 was complex and mediated by various processes. Among the altered gene expressions, the genes involved in immune and inflammation processes were selectively down-regulated, such as cytokines and cytokine receptors (TNFSF14, TNF, TNFRSF6, and IL1A), chemokines (CCL8 and CXCL11), JAK/STAT signaling (JAK3 and STAT5A), TLRs family (TLR4 and TLR8) and NF-κB (NFKB1). Expression of some genes was validated using RT-PCR. The results demonstrated that AP1, AP2 and AP3 exhibited the anti-inflammatory effect by interfering COX and inflammatory cytokines and the underlying mechanisms of AP2 may be related to down-expression of genes involved in inflammatory cascade." @default.
• W2077672218 created "2016-06-24" @default.
• W2077672218 creator A5001713646 @default.
• W2077672218 creator A5002876209 @default.
• W2077672218 creator A5010077516 @default.
• W2077672218 creator A5084804811 @default.
• W2077672218 date "2010-11-01" @default.
• W2077672218 modified "2023-09-25" @default.
• W2077672218 title "Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression" @default.
• W2077672218 cites W1491294744 @default.
• W2077672218 cites W1590553747 @default.
• W2077672218 cites W165055088 @default.
• W2077672218 cites W1967492443 @default.
• W2077672218 cites W1975871282 @default.
• W2077672218 cites W1976452827 @default.
• W2077672218 cites W1979580921 @default.
• W2077672218 cites W1988720071 @default.
• W2077672218 cites W1989246729 @default.
• W2077672218 cites W1990092707 @default.
• W2077672218 cites W1996174176 @default.
• W2077672218 cites W1998394615 @default.
• W2077672218 cites W2014993313 @default.
• W2077672218 cites W2016648276 @default.
• W2077672218 cites W2017516341 @default.
• W2077672218 cites W2021239799 @default.
• W2077672218 cites W2023116833 @default.
• W2077672218 cites W2030105128 @default.
• W2077672218 cites W2032611317 @default.
• W2077672218 cites W2033557539 @default.
• W2077672218 cites W2036767516 @default.
• W2077672218 cites W2038481001 @default.
• W2077672218 cites W2039681893 @default.
• W2077672218 cites W2042059400 @default.
• W2077672218 cites W2044258256 @default.
• W2077672218 cites W2055022595 @default.
• W2077672218 cites W2056686776 @default.
• W2077672218 cites W2056933088 @default.
• W2077672218 cites W2057385802 @default.
• W2077672218 cites W2058259319 @default.
• W2077672218 cites W2061631515 @default.
• W2077672218 cites W2066713292 @default.
• W2077672218 cites W2085297686 @default.
• W2077672218 cites W2088455943 @default.
• W2077672218 cites W2089486556 @default.
• W2077672218 cites W2090969569 @default.
• W2077672218 cites W2103017472 @default.
• W2077672218 cites W2106323366 @default.
• W2077672218 cites W2126853519 @default.
• W2077672218 cites W2133043485 @default.
• W2077672218 cites W2331176038 @default.
• W2077672218 cites W2950744081 @default.
• W2077672218 cites W4294216483 @default.
• W2077672218 doi "https://doi.org/10.1016/j.intimp.2010.08.002" @default.
• W2077672218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20728594" @default.
• W2077672218 hasPublicationYear "2010" @default.
• W2077672218 type Work @default.
• W2077672218 sameAs 2077672218 @default.
• W2077672218 citedByCount "81" @default.
• W2077672218 countsByYear W20776722182012 @default.
• W2077672218 countsByYear W20776722182013 @default.
• W2077672218 countsByYear W20776722182014 @default.
• W2077672218 countsByYear W20776722182015 @default.
• W2077672218 countsByYear W20776722182016 @default.
• W2077672218 countsByYear W20776722182017 @default.
• W2077672218 countsByYear W20776722182018 @default.
• W2077672218 countsByYear W20776722182019 @default.
• W2077672218 countsByYear W20776722182020 @default.
• W2077672218 countsByYear W20776722182021 @default.
• W2077672218 countsByYear W20776722182022 @default.
• W2077672218 countsByYear W20776722182023 @default.
• W2077672218 crossrefType "journal-article" @default.
• W2077672218 hasAuthorship W2077672218A5001713646 @default.
• W2077672218 hasAuthorship W2077672218A5002876209 @default.
• W2077672218 hasAuthorship W2077672218A5010077516 @default.
• W2077672218 hasAuthorship W2077672218A5084804811 @default.
• W2077672218 hasConcept C104317684 @default.
• W2077672218 hasConcept C13373296 @default.
• W2077672218 hasConcept C142724271 @default.
• W2077672218 hasConcept C150194340 @default.
• W2077672218 hasConcept C153911025 @default.
• W2077672218 hasConcept C164027704 @default.
• W2077672218 hasConcept C17991360 @default.
• W2077672218 hasConcept C185592680 @default.
• W2077672218 hasConcept C203014093 @default.
• W2077672218 hasConcept C204787440 @default.
• W2077672218 hasConcept C2776070231 @default.
• W2077672218 hasConcept C2776914184 @default.
• W2077672218 hasConcept C2777970627 @default.
• W2077672218 hasConcept C2778690821 @default.
• W2077672218 hasConcept C2781357234 @default.
• W2077672218 hasConcept C55493867 @default.
• W2077672218 hasConcept C71924100 @default.
• W2077672218 hasConcept C86803240 @default.
• W2077672218 hasConcept C8891405 @default.
• W2077672218 hasConcept C98274493 @default.
• W2077672218 hasConceptScore W2077672218C104317684 @default.
• W2077672218 hasConceptScore W2077672218C13373296 @default.
• W2077672218 hasConceptScore W2077672218C142724271 @default.

• next