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• W2077680786 abstract "<h3>Objectives:</h3> To determine the incidence of human papillomavirus (HPV) infection and<i>p</i>53 gene mutation expression in squamous cell carcinomas (SCCs) of the oral cavity and tonsils, to correlate the presence of HPV and<i>p</i>53 gene mutation with known clinical and pathological features of SCC, and to determine whether infection with HPV or the presence of<i>p</i>53 gene mutations are independent prognosticators of patient survival. <h3>Design:</h3> To accomplish this goal, 58 patients with SCCs of the oral cavity and 42 patients with SCCs of the tonsils were randomly examined. The cases examined met the criteria of 5-year clinical follow-up, availability of complete staging information and treatment history, and the presence of paraffin-embedded tumor specimens. Immunohistochemical tests were performed to identify the mutant p53 protein. Human papillomavirus identification was accomplished with polymerase chain reaction, with confirmation via restriction fragment length polymorphisms. <h3>Results:</h3> The incidence of<i>p</i>53 gene mutation expression for this series was 66%. Human papillomavirus infection was found in 11 patients (11%). There was a trend toward increased<i>p</i>53 gene mutation expression with advancing stage of tumor in the oral cavity cancer group, although this was less evident in the tonsil cancer population. The<i>p</i>53 gene mutation status was found not to correlate with the histological grade of the tumor, patient age or sex, recurrence rates, or survival status. Like<i>p</i>53 expression, there were no correlations found between the presence of HPV and age, sex, histological grade, or recurrence rates. However, a correlation did exist between HPV and survival status in the tonsil cancer group, with improved survival noted among patients with tonsil cancers infected with HPV compared with those not infected with HPV. A significant correlation existed with both<i>p</i>53 gene mutation status and HPV status with respect to alcohol and tobacco use. The presence of the<i>p</i>53 gene mutation positively correlated with increased tobacco and alcohol use, whereas infection with HPV predicted a significantly lower rate of alcohol and tobacco consumption. <h3>Conclusions:</h3> Human papillomavirus infection is an independent risk factor for the development of oral cavity and tonsil SCCs in those patients with a relatively low alcohol and tobacco use history. Conversely, there is a strong association between heavy alcohol and tobacco use and mutation of the<i>p</i>53 gene. Neither<i>p</i>53 gene mutation nor HPV infection serve as prognosticators of tumor behavior in SCCs of the oral cavity or tonsils, with the exception of improved survival noted among patients with tonsil cancers infected with HPV. Arch Otolaryngol Head Neck Surg. 1997;123:1230-1234" @default.
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• W2077680786 date "1997-11-01" @default.
• W2077680786 modified "2023-09-24" @default.
• W2077680786 title "Human Papillomavirus Expression and p53 Gene Mutations in Squamous Cell Carcinoma" @default.
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• W2077680786 doi "https://doi.org/10.1001/archotol.1997.01900110084011" @default.
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