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- W2077681134 abstract "Chronic intermittent hypoxia (CIH) induces changes in the cardiovascular and respiratory neural control, including reduction in afferent neurotransmission on nucleus tractus solitarii (NTS) neurons. Here we studied the mechanisms involved in this reduction in NTS neurons of CIH rats. Male juvenile rats were exposed to 10 days of CIH and after this period, Tractus Solitarii (TS)-evoked glutamatergic post-synaptic currents (eEPSCs) were recorded in horizontal brainstem slices. Neurons were classified according to the standard deviation (SD) of latency for eEPSCs as 2nd-order neurons (latency SD<250 μs) and putative higher-order neurons (latency SD>250 μs). CIH reduced the amplitude of eEPSCs in 2nd-order neurons (325±22 vs. 187±10 pA, n=58; P<0.0001) but did not affect eEPSC amplitudes of higher-order neurons (102±19 vs. 113±16 pA, n=20; P>0.05). Concerning the mechanisms of eEPSC reduction in 2nd-order neurons we documented that: a) CIH produced no change in the short-term depression of eEPSCs, suggesting the absence of changes in release probability; b) a post-synaptic effect of CIH is ruled out because the amplitude of asynchronous EPSCs evoked in the presence of 2 mM of strontium (Sr2+) were similar in both groups; and c) the total number of asynchronous eEPSCs was significantly reduced after CIH, suggesting a decrease in the number of functional synapses. To address the latter possibility we used a minimal stimulation protocol of the TS and verified that the amplitude of putative single-fiber eEPSCs was diminished after CIH (17.6±0.6 vs. 16±0.5 pA, n=22, P<0.05) and the estimated number of afferent fibers was greatly reduced (24±2 vs. 12±1 fibers, n=22, P<0.0001). These findings support the concept that CIH selectively depresses TS-evoked glutamatergic synaptic transmission on 2nd-order NTS neurons by a reduction in the number of functional synapses." @default.
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- W2077681134 date "2011-09-01" @default.
- W2077681134 modified "2023-09-26" @default.
- W2077681134 title "Depressed TS-evoked glutamatergic transmission on NTS neurons of rats submitted to intermittent hypoxia is due to reduced number of functional synapses" @default.
- W2077681134 doi "https://doi.org/10.1016/j.autneu.2011.05.133" @default.
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