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- W2077681308 abstract "The optimal treatment of patients with non-small cell lung cancer is increasingly being determined by the mutation analysis of the tumour. Despite this fact however the majority of patients with this condition will be candidates for palliative chemotherapy. The choice of chemotherapy for older adults with NSCLC depends not only on the histology (adenocarcinoma vs squamous cell) but the feasibility of the patient to tolerate standard, platinum doublet therapy. Whereas early studies of chemotherapy exclusively in older patients mostly utilized single agents in patients over 70 years, subsequent research supports the use of platinum doublets regardless of age. Clinical trials such as that conducted by Quoix et al. show that older patients derive a survival benefit from platinum doublets. This has led to a change in the treatment recommendations from agencies such as the NCCN2. The standard of care is now a platinum doublet where possible. This is a different approach from the previous recommendations of single agents such as gemcitabine and vinorelbine." @default.
- W2077681308 created "2016-06-24" @default.
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- W2077681308 date "2014-07-01" @default.
- W2077681308 modified "2023-09-26" @default.
- W2077681308 title "OLDER ADULTS WITH ADVANCED STAGE LUNG CANCER — WHAT IS THE OPTIMAL THERAPY?" @default.
- W2077681308 cites W2121095198 @default.
- W2077681308 doi "https://doi.org/10.1016/j.jgo.2014.06.044" @default.
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