FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077681906> ?p ?o ?g. }

• W2077681906 endingPage "416" @default.
• W2077681906 startingPage "408" @default.
• W2077681906 abstract "Summary Dysfunction of human cavernous endothelial cells (HCECs) is a common pathological alteration caused by elevated high blood glucose levels associated with diabetes. To explore the protective effects of Icariside II (ICA II) on human cavernous endothelial cells, HCECs were isolated from non‐diabetic human donors, cultured under high glucose (HG) conditions and treated with ICA II. The cell apoptosis and proliferation, expression of Ki67 and Erk1/2, antioxidant capacity, and expression of Akt and eNOS were examined. Changes in cell apoptosis and proliferation indicated that HG treatment inhibited HCEC proliferation with lower percentage of Ki67‐positive cells and lower expression and phosphorylation of Erk1/2. Furthermore, the total antioxidant capacity (T‐AOC) of HCECs was reduced under HG conditions. In line with these findings, both expression and phosphorylation of Akt as well as eNOS was down regulated after HG treatment. The reduction in proliferative capacity, p‐Erk1/2, p‐Akt, and p‐ eNOS were partially prevented by ICA II in a concentration‐dependent manner. The protective effects of ICA II rescued HCEC from injury and dysfunction induced by HG in vitro. ICA II may be a candidate for prevention of the development of diabetic erectile dysfunction." @default.
• W2077681906 created "2016-06-24" @default.
• W2077681906 creator A5017254585 @default.
• W2077681906 creator A5021228188 @default.
• W2077681906 creator A5028497420 @default.
• W2077681906 creator A5041519779 @default.
• W2077681906 creator A5045806343 @default.
• W2077681906 creator A5051298638 @default.
• W2077681906 creator A5053945350 @default.
• W2077681906 creator A5054667123 @default.
• W2077681906 creator A5070324288 @default.
• W2077681906 creator A5072773646 @default.
• W2077681906 creator A5088330075 @default.
• W2077681906 date "2015-01-08" @default.
• W2077681906 modified "2023-10-06" @default.
• W2077681906 title "Icariside II prevents high-glucose-induced injury on human cavernous endothelial cells through Akt-eNOS signaling pathway" @default.
• W2077681906 cites W1608724580 @default.
• W2077681906 cites W1857538529 @default.
• W2077681906 cites W1969148502 @default.
• W2077681906 cites W1969877794 @default.
• W2077681906 cites W1973761281 @default.
• W2077681906 cites W1981478994 @default.
• W2077681906 cites W1982054742 @default.
• W2077681906 cites W1989298176 @default.
• W2077681906 cites W2000496492 @default.
• W2077681906 cites W2008062232 @default.
• W2077681906 cites W2008513516 @default.
• W2077681906 cites W2015426450 @default.
• W2077681906 cites W2022142901 @default.
• W2077681906 cites W2023167090 @default.
• W2077681906 cites W2025571804 @default.
• W2077681906 cites W2038095540 @default.
• W2077681906 cites W2041570673 @default.
• W2077681906 cites W2050899682 @default.
• W2077681906 cites W2052274644 @default.
• W2077681906 cites W2053369310 @default.
• W2077681906 cites W2056072510 @default.
• W2077681906 cites W2066522330 @default.
• W2077681906 cites W2072454523 @default.
• W2077681906 cites W2078047202 @default.
• W2077681906 cites W2080791333 @default.
• W2077681906 cites W2081236313 @default.
• W2077681906 cites W2086413242 @default.
• W2077681906 cites W2088454193 @default.
• W2077681906 cites W2090191790 @default.
• W2077681906 cites W2134849333 @default.
• W2077681906 cites W2142793025 @default.
• W2077681906 cites W2152805847 @default.
• W2077681906 cites W2158968180 @default.
• W2077681906 cites W2165685377 @default.
• W2077681906 doi "https://doi.org/10.1111/andr.303" @default.
• W2077681906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25641754" @default.
• W2077681906 hasPublicationYear "2015" @default.
• W2077681906 type Work @default.
• W2077681906 sameAs 2077681906 @default.
• W2077681906 citedByCount "13" @default.
• W2077681906 countsByYear W20776819062015 @default.
• W2077681906 countsByYear W20776819062017 @default.
• W2077681906 countsByYear W20776819062018 @default.
• W2077681906 countsByYear W20776819062019 @default.
• W2077681906 countsByYear W20776819062021 @default.
• W2077681906 countsByYear W20776819062022 @default.
• W2077681906 countsByYear W20776819062023 @default.
• W2077681906 crossrefType "journal-article" @default.
• W2077681906 hasAuthorship W2077681906A5017254585 @default.
• W2077681906 hasAuthorship W2077681906A5021228188 @default.
• W2077681906 hasAuthorship W2077681906A5028497420 @default.
• W2077681906 hasAuthorship W2077681906A5041519779 @default.
• W2077681906 hasAuthorship W2077681906A5045806343 @default.
• W2077681906 hasAuthorship W2077681906A5051298638 @default.
• W2077681906 hasAuthorship W2077681906A5053945350 @default.
• W2077681906 hasAuthorship W2077681906A5054667123 @default.
• W2077681906 hasAuthorship W2077681906A5070324288 @default.
• W2077681906 hasAuthorship W2077681906A5072773646 @default.
• W2077681906 hasAuthorship W2077681906A5088330075 @default.
• W2077681906 hasConcept C11960822 @default.
• W2077681906 hasConcept C126322002 @default.
• W2077681906 hasConcept C134018914 @default.
• W2077681906 hasConcept C185592680 @default.
• W2077681906 hasConcept C190283241 @default.
• W2077681906 hasConcept C2777622882 @default.
• W2077681906 hasConcept C2778326061 @default.
• W2077681906 hasConcept C2780972559 @default.
• W2077681906 hasConcept C519581460 @default.
• W2077681906 hasConcept C55493867 @default.
• W2077681906 hasConcept C71924100 @default.
• W2077681906 hasConcept C75217442 @default.
• W2077681906 hasConcept C86803240 @default.
• W2077681906 hasConcept C95444343 @default.
• W2077681906 hasConcept C98274493 @default.
• W2077681906 hasConceptScore W2077681906C11960822 @default.
• W2077681906 hasConceptScore W2077681906C126322002 @default.
• W2077681906 hasConceptScore W2077681906C134018914 @default.
• W2077681906 hasConceptScore W2077681906C185592680 @default.
• W2077681906 hasConceptScore W2077681906C190283241 @default.
• W2077681906 hasConceptScore W2077681906C2777622882 @default.
• W2077681906 hasConceptScore W2077681906C2778326061 @default.
• W2077681906 hasConceptScore W2077681906C2780972559 @default.

• next