FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077683600> ?p ?o ?g. }

• W2077683600 endingPage "3263" @default.
• W2077683600 startingPage "3257" @default.
• W2077683600 abstract "ABSTRACT In light of the need for new antifungal agents, the candidacidal activities of human lactoferrin (hLF) and synthetic peptides representing the first, hLF(1-11), and second, hLF(21-31), cationic domains of its N terminus were compared. The results revealed that hLF(1-11) was more effective in killing fluconazole-resistant Candida albicans than hLF(21-31) and much more effective than lactoferrin, as determined microbiologically and by propidium iodide (PI) staining. By using hLF(1-11) and various derivatives, it was found that the second and third residues of the N terminus of hLF(1-11) were critical for its candidacidal activity. Detailed investigation to elucidate the mechanism of action of hLF(1-11) revealed a dose-dependent release of ATP by Candida upon exposure to hLF(1-11). Our observations that sodium azide reduced the PI uptake and candidacidal activity of hLF(1-11) and that, upon exposure to hLF(1-11), the fluorescent dye rhodamine 123 first accumulated inside the mitochondria and later was released into the cytoplasm indicate that the peptide triggers the energized mitochondrion. Furthermore, oxidized ATP, which interferes with the interaction of ATP with its extracellular receptors, blocked the candidacidal action of hLF(1-11), as measured microbiologically and by PI staining. Addition of ATP (or analogues) was not a sufficient stimulus to kill C. albicans or to act synergistically with suboptimal concentrations of the peptide. The main conclusions are that the first two arginines at the N terminus of hLF are critical in the candidacidal activity of hLF(1-11) and that extracellular ATP is essential but not sufficient for the peptide to exert its candidacidal activity." @default.
• W2077683600 created "2016-06-24" @default.
• W2077683600 creator A5009501506 @default.
• W2077683600 creator A5011409066 @default.
• W2077683600 creator A5012033996 @default.
• W2077683600 creator A5030344798 @default.
• W2077683600 creator A5062066729 @default.
• W2077683600 creator A5062793956 @default.
• W2077683600 date "2000-12-01" @default.
• W2077683600 modified "2023-09-27" @default.
• W2077683600 title "Candidacidal Activities of Human Lactoferrin Peptides Derived from the N Terminus" @default.
• W2077683600 cites W1516305992 @default.
• W2077683600 cites W1788127540 @default.
• W2077683600 cites W1831024764 @default.
• W2077683600 cites W1965171553 @default.
• W2077683600 cites W1972312757 @default.
• W2077683600 cites W1972733192 @default.
• W2077683600 cites W1974945118 @default.
• W2077683600 cites W1982593621 @default.
• W2077683600 cites W1982664201 @default.
• W2077683600 cites W1984706012 @default.
• W2077683600 cites W1992725525 @default.
• W2077683600 cites W1996085928 @default.
• W2077683600 cites W1997357193 @default.
• W2077683600 cites W2004373761 @default.
• W2077683600 cites W2010557022 @default.
• W2077683600 cites W2010999630 @default.
• W2077683600 cites W2018109588 @default.
• W2077683600 cites W2039933988 @default.
• W2077683600 cites W2040310992 @default.
• W2077683600 cites W2047795757 @default.
• W2077683600 cites W2057700691 @default.
• W2077683600 cites W2074421138 @default.
• W2077683600 cites W2080267955 @default.
• W2077683600 cites W2086306477 @default.
• W2077683600 cites W2091874747 @default.
• W2077683600 cites W2103805019 @default.
• W2077683600 cites W2105639660 @default.
• W2077683600 cites W2106772897 @default.
• W2077683600 cites W2111004265 @default.
• W2077683600 cites W2113423265 @default.
• W2077683600 cites W2121496462 @default.
• W2077683600 cites W2122974015 @default.
• W2077683600 cites W2123781280 @default.
• W2077683600 cites W2126075289 @default.
• W2077683600 cites W2135089333 @default.
• W2077683600 cites W2144599944 @default.
• W2077683600 cites W2147094062 @default.
• W2077683600 cites W2159432238 @default.
• W2077683600 cites W2161124891 @default.
• W2077683600 cites W2168544211 @default.
• W2077683600 cites W4244732422 @default.
• W2077683600 cites W4255507877 @default.
• W2077683600 doi "https://doi.org/10.1128/aac.44.12.3257-3263.2000" @default.
• W2077683600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/90189" @default.
• W2077683600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11083624" @default.
• W2077683600 hasPublicationYear "2000" @default.
• W2077683600 type Work @default.
• W2077683600 sameAs 2077683600 @default.
• W2077683600 citedByCount "119" @default.
• W2077683600 countsByYear W20776836002012 @default.
• W2077683600 countsByYear W20776836002013 @default.
• W2077683600 countsByYear W20776836002014 @default.
• W2077683600 countsByYear W20776836002015 @default.
• W2077683600 countsByYear W20776836002016 @default.
• W2077683600 countsByYear W20776836002017 @default.
• W2077683600 countsByYear W20776836002018 @default.
• W2077683600 countsByYear W20776836002019 @default.
• W2077683600 countsByYear W20776836002020 @default.
• W2077683600 countsByYear W20776836002021 @default.
• W2077683600 countsByYear W20776836002022 @default.
• W2077683600 countsByYear W20776836002023 @default.
• W2077683600 crossrefType "journal-article" @default.
• W2077683600 hasAuthorship W2077683600A5009501506 @default.
• W2077683600 hasAuthorship W2077683600A5011409066 @default.
• W2077683600 hasAuthorship W2077683600A5012033996 @default.
• W2077683600 hasAuthorship W2077683600A5030344798 @default.
• W2077683600 hasAuthorship W2077683600A5062066729 @default.
• W2077683600 hasAuthorship W2077683600A5062793956 @default.
• W2077683600 hasBestOaLocation W20776836002 @default.
• W2077683600 hasConcept C185592680 @default.
• W2077683600 hasConcept C190283241 @default.
• W2077683600 hasConcept C202751555 @default.
• W2077683600 hasConcept C2775934118 @default.
• W2077683600 hasConcept C2776120743 @default.
• W2077683600 hasConcept C2779170986 @default.
• W2077683600 hasConcept C2779281246 @default.
• W2077683600 hasConcept C2780917455 @default.
• W2077683600 hasConcept C28406088 @default.
• W2077683600 hasConcept C31573885 @default.
• W2077683600 hasConcept C55493867 @default.
• W2077683600 hasConcept C86803240 @default.
• W2077683600 hasConcept C89423630 @default.
• W2077683600 hasConceptScore W2077683600C185592680 @default.
• W2077683600 hasConceptScore W2077683600C190283241 @default.
• W2077683600 hasConceptScore W2077683600C202751555 @default.
• W2077683600 hasConceptScore W2077683600C2775934118 @default.
• W2077683600 hasConceptScore W2077683600C2776120743 @default.

• next