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• W2077686970 abstract "A high yielding unambiguous synthesis of (±)-6-alkyl-5,6,7,8-tetrahydropterin 5a–f hydrochlorides starting from ethyl α-isocyanoacetate 1 and the respective alkanoic anhydrides or alkanoyl chlorides in four steps is described. All the six pterins 5a–f that have been synthesised are substrates for mammalian phenylalanine, tryptophan and tyrosine hydroxylases and their activities have been compared with those of natural 6R-tetrahydrobiopterin under similar conditions. The data allowed the choice of 6-n-propyl-5,6,7,8-tetrahydropterin 5c for further studies as a candidate for tetrahydrobiopterin drug therapy. On décrit une synthèse non équivoque des chlorhydrates des (±)alkyl-6-tétrahydro-5,6,7,8 ptérines 5a–f avec de hauts rendements à partir de l'α-isocyanacétate d'éthyle 1 et les anhydrides ou les chlorures d'acides correspondants en quatre étapes. Les six ptérines 5a–f que nous avons préparées sont des bons substrats des hydroxylases de la phénylalanine, du tryptophane et de la tyrosine provenant de mammifères, et leurs activités ont été comparées avec celles de la tétrahydrobioptérine naturelle dans des conditions semblables. Les résultats permettent de choisir la n-propyl-6 tétrahydro-5,6,7,8 ptérine 5c pour des études futures." @default.
• W2077686970 created "2016-06-24" @default.
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• W2077686970 date "1987-07-01" @default.
• W2077686970 modified "2023-09-23" @default.
• W2077686970 title "Lipophilic 5,6,7,8-tetrahydropterin substrates for phenylalanine hydroxylase (monkey brain), tryptophan hydroxylase (rat brain) and tyrosine hydroxylase (rat brain)" @default.
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• W2077686970 doi "https://doi.org/10.1016/0223-5234(87)90265-0" @default.
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