Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077687583> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2077687583 endingPage "S161" @default.
- W2077687583 startingPage "S161" @default.
- W2077687583 abstract "618 Introduction: SangCya™ is a FDA approved cyclosporine (CyA) formulation demonstrated to be bioequivalent to Neoral® in normal subjects and transplant recipients (kidney and liver). This study was designed to compare CyA pharmacokinetic (PK) parameters and long-term clinical tolerability between SangCya and Neoral in stable renal transplant (RT) recipients. Methods: Stable RT recipients were assigned a randomized sequence to receive SangCya and Neoral oral solutions in a double-blind, 2-way crossover study (Part I). The same dosage either formulation was given for 7 days. PK parameters of CyA were evaluated at the end of each crossover period. The second assigned treatment was continued for 12 months in a blinded manner to assess clinical tolerability (Part II). Results: 42 patients completed PK studies and 39 have completed 3 months follow-up. The 42 patients included 30 (71%) males, 11 (26%) African Americans, and 8 (19%) diabetic recipients. At enrollment mean ± SD age was 47 ± 11 years, and 5 ± 2 years posttransplant. Part I results: (Table)TableIn Part II of the study, 19 patients received SangCya and 20 received Neoral. There have been no graft losses or acute rejections after 3 months follow-up. Serum creatinine (Cr) levels have remained stable. (Table)TableConclusions: SangCya and Neoral have similar CyA PK parameters and clinical tolerability over 3 months in stable RT recipients. In this study, there were no significant differences between the two CyA formulations. Funded by SangStat Medical Corporation, Menlo Park, CA." @default.
- W2077687583 created "2016-06-24" @default.
- W2077687583 creator A5017765749 @default.
- W2077687583 creator A5022127781 @default.
- W2077687583 creator A5084070535 @default.
- W2077687583 creator A5088499999 @default.
- W2077687583 date "1999-04-01" @default.
- W2077687583 modified "2023-09-27" @default.
- W2077687583 title "PHARMACOKINETIC AND CLINICAL EVALUATION OF SANGCYA AND NEORAL IN STABLE, ADULT RENAL TRANSPLANT PATIENTS: PRELIMINARY RESULTS" @default.
- W2077687583 doi "https://doi.org/10.1097/00007890-199904150-00643" @default.
- W2077687583 hasPublicationYear "1999" @default.
- W2077687583 type Work @default.
- W2077687583 sameAs 2077687583 @default.
- W2077687583 citedByCount "2" @default.
- W2077687583 countsByYear W20776875832016 @default.
- W2077687583 crossrefType "journal-article" @default.
- W2077687583 hasAuthorship W2077687583A5017765749 @default.
- W2077687583 hasAuthorship W2077687583A5022127781 @default.
- W2077687583 hasAuthorship W2077687583A5084070535 @default.
- W2077687583 hasAuthorship W2077687583A5088499999 @default.
- W2077687583 hasBestOaLocation W20776875831 @default.
- W2077687583 hasConcept C112705442 @default.
- W2077687583 hasConcept C126322002 @default.
- W2077687583 hasConcept C126894567 @default.
- W2077687583 hasConcept C141071460 @default.
- W2077687583 hasConcept C142724271 @default.
- W2077687583 hasConcept C159641895 @default.
- W2077687583 hasConcept C197934379 @default.
- W2077687583 hasConcept C204787440 @default.
- W2077687583 hasConcept C27081682 @default.
- W2077687583 hasConcept C2778375690 @default.
- W2077687583 hasConcept C2780306776 @default.
- W2077687583 hasConcept C2911091166 @default.
- W2077687583 hasConcept C42404028 @default.
- W2077687583 hasConcept C71924100 @default.
- W2077687583 hasConcept C87813604 @default.
- W2077687583 hasConcept C90924648 @default.
- W2077687583 hasConceptScore W2077687583C112705442 @default.
- W2077687583 hasConceptScore W2077687583C126322002 @default.
- W2077687583 hasConceptScore W2077687583C126894567 @default.
- W2077687583 hasConceptScore W2077687583C141071460 @default.
- W2077687583 hasConceptScore W2077687583C142724271 @default.
- W2077687583 hasConceptScore W2077687583C159641895 @default.
- W2077687583 hasConceptScore W2077687583C197934379 @default.
- W2077687583 hasConceptScore W2077687583C204787440 @default.
- W2077687583 hasConceptScore W2077687583C27081682 @default.
- W2077687583 hasConceptScore W2077687583C2778375690 @default.
- W2077687583 hasConceptScore W2077687583C2780306776 @default.
- W2077687583 hasConceptScore W2077687583C2911091166 @default.
- W2077687583 hasConceptScore W2077687583C42404028 @default.
- W2077687583 hasConceptScore W2077687583C71924100 @default.
- W2077687583 hasConceptScore W2077687583C87813604 @default.
- W2077687583 hasConceptScore W2077687583C90924648 @default.
- W2077687583 hasIssue "7" @default.
- W2077687583 hasLocation W20776875831 @default.
- W2077687583 hasLocation W20776875832 @default.
- W2077687583 hasOpenAccess W2077687583 @default.
- W2077687583 hasPrimaryLocation W20776875831 @default.
- W2077687583 hasRelatedWork W1486584413 @default.
- W2077687583 hasRelatedWork W1996704093 @default.
- W2077687583 hasRelatedWork W2087086071 @default.
- W2077687583 hasRelatedWork W2348452531 @default.
- W2077687583 hasRelatedWork W2356170336 @default.
- W2077687583 hasRelatedWork W2357220270 @default.
- W2077687583 hasRelatedWork W2376025896 @default.
- W2077687583 hasRelatedWork W2381009208 @default.
- W2077687583 hasRelatedWork W3146022116 @default.
- W2077687583 hasRelatedWork W4205357787 @default.
- W2077687583 hasVolume "67" @default.
- W2077687583 isParatext "false" @default.
- W2077687583 isRetracted "false" @default.
- W2077687583 magId "2077687583" @default.
- W2077687583 workType "article" @default.