FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077690129> ?p ?o ?g. }

• W2077690129 endingPage "197" @default.
• W2077690129 startingPage "190" @default.
• W2077690129 abstract "In this study, we investigated the effects of delta-opioid receptor antagonists on the G protein-coupled inwardly rectifying potassium (GIRK) channel currents induced by serotonin (5-HT) and noradrenaline (NAd) in the dorsal raphe and the locus coeruleus neurons, respectively. Perforated patch and conventional whole-cell patch clamp recording techniques were used for the study. Neurons were acutely dissociated from neonatal rats. Both naltrindole (NTI) and naltriben (NTB), which are selective delta-antagonists possessing antitussive activity in in vivo animal studies, reversibly inhibited the 5-HT-induced GIRK channel currents (I(5-HT)) in dorsal raphe neurons. This inhibition was concentration-dependent and voltage-independent. The half-maximum inhibitory concentration (IC(50)) on I(5-HT) was 9.84x10(-5) M for NTI and 1.28x10(-5) M for NTB. The inhibition was not reversed by 10(-5) M DPDPE, a selective delta-opioid receptor agonist. NTI did not affect 50% effective concentration (EC(50)) on the concentration-response relationship for 5-HT but inhibited the maximum response. In neurons internally perfused with GTPgammaS, both NTI and NTB also inhibited the GIRK channel currents irreversibly activated by 5-HT. Furthermore, these antagonists concentration dependently inhibited 10(-6) M NAd-induced currents (I(NAd)) in locus coeruleus neurons. The IC(50) of NTI on I(NAd) was 8.44x10(-5) M, which was close to that on I(5-HT). The results suggest that NTI and NTB, which are delta-opioid receptor antagonists possessing antitussive activity, may inhibit GIRK channel currents through a non-opioid action, and give further support to our idea previously proposed that centrally acting non-narcotic antitussives have a common characteristic of the inhibitory action on GIRK channels." @default.
• W2077690129 created "2016-06-24" @default.
• W2077690129 creator A5006363492 @default.
• W2077690129 creator A5026994272 @default.
• W2077690129 creator A5038934637 @default.
• W2077690129 creator A5065196251 @default.
• W2077690129 date "2004-05-01" @default.
• W2077690129 modified "2023-09-25" @default.
• W2077690129 title "δ-Opioid receptor antagonists inhibit GIRK channel currents in acutely dissociated brainstem neurons of rat" @default.
• W2077690129 cites W1790229448 @default.
• W2077690129 cites W1797736032 @default.
• W2077690129 cites W1971233991 @default.
• W2077690129 cites W1989436490 @default.
• W2077690129 cites W1992232101 @default.
• W2077690129 cites W2000999114 @default.
• W2077690129 cites W2006112766 @default.
• W2077690129 cites W2014580405 @default.
• W2077690129 cites W2016983964 @default.
• W2077690129 cites W2020743895 @default.
• W2077690129 cites W2042023583 @default.
• W2077690129 cites W2042848465 @default.
• W2077690129 cites W2042907111 @default.
• W2077690129 cites W2043023167 @default.
• W2077690129 cites W2045579427 @default.
• W2077690129 cites W2063069260 @default.
• W2077690129 cites W2063906666 @default.
• W2077690129 cites W2082958216 @default.
• W2077690129 cites W2090981990 @default.
• W2077690129 cites W2092585003 @default.
• W2077690129 cites W2106016755 @default.
• W2077690129 cites W2126931614 @default.
• W2077690129 cites W2157090929 @default.
• W2077690129 cites W2165498557 @default.
• W2077690129 cites W2166105988 @default.
• W2077690129 doi "https://doi.org/10.1016/j.brainres.2004.02.004" @default.
• W2077690129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15051522" @default.
• W2077690129 hasPublicationYear "2004" @default.
• W2077690129 type Work @default.
• W2077690129 sameAs 2077690129 @default.
• W2077690129 citedByCount "9" @default.
• W2077690129 countsByYear W20776901292012 @default.
• W2077690129 countsByYear W20776901292015 @default.
• W2077690129 countsByYear W20776901292018 @default.
• W2077690129 countsByYear W20776901292019 @default.
• W2077690129 countsByYear W20776901292023 @default.
• W2077690129 crossrefType "journal-article" @default.
• W2077690129 hasAuthorship W2077690129A5006363492 @default.
• W2077690129 hasAuthorship W2077690129A5026994272 @default.
• W2077690129 hasAuthorship W2077690129A5038934637 @default.
• W2077690129 hasAuthorship W2077690129A5065196251 @default.
• W2077690129 hasConcept C126322002 @default.
• W2077690129 hasConcept C134018914 @default.
• W2077690129 hasConcept C142652207 @default.
• W2077690129 hasConcept C170493617 @default.
• W2077690129 hasConcept C185592680 @default.
• W2077690129 hasConcept C2775864247 @default.
• W2077690129 hasConcept C2777953665 @default.
• W2077690129 hasConcept C2778468602 @default.
• W2077690129 hasConcept C2778938600 @default.
• W2077690129 hasConcept C2779886867 @default.
• W2077690129 hasConcept C32610206 @default.
• W2077690129 hasConcept C37000724 @default.
• W2077690129 hasConcept C529278444 @default.
• W2077690129 hasConcept C55493867 @default.
• W2077690129 hasConcept C71924100 @default.
• W2077690129 hasConcept C80631254 @default.
• W2077690129 hasConcept C83743174 @default.
• W2077690129 hasConcept C86803240 @default.
• W2077690129 hasConcept C98274493 @default.
• W2077690129 hasConceptScore W2077690129C126322002 @default.
• W2077690129 hasConceptScore W2077690129C134018914 @default.
• W2077690129 hasConceptScore W2077690129C142652207 @default.
• W2077690129 hasConceptScore W2077690129C170493617 @default.
• W2077690129 hasConceptScore W2077690129C185592680 @default.
• W2077690129 hasConceptScore W2077690129C2775864247 @default.
• W2077690129 hasConceptScore W2077690129C2777953665 @default.
• W2077690129 hasConceptScore W2077690129C2778468602 @default.
• W2077690129 hasConceptScore W2077690129C2778938600 @default.
• W2077690129 hasConceptScore W2077690129C2779886867 @default.
• W2077690129 hasConceptScore W2077690129C32610206 @default.
• W2077690129 hasConceptScore W2077690129C37000724 @default.
• W2077690129 hasConceptScore W2077690129C529278444 @default.
• W2077690129 hasConceptScore W2077690129C55493867 @default.
• W2077690129 hasConceptScore W2077690129C71924100 @default.
• W2077690129 hasConceptScore W2077690129C80631254 @default.
• W2077690129 hasConceptScore W2077690129C83743174 @default.
• W2077690129 hasConceptScore W2077690129C86803240 @default.
• W2077690129 hasConceptScore W2077690129C98274493 @default.
• W2077690129 hasIssue "2" @default.
• W2077690129 hasLocation W20776901291 @default.
• W2077690129 hasLocation W20776901292 @default.
• W2077690129 hasOpenAccess W2077690129 @default.
• W2077690129 hasPrimaryLocation W20776901291 @default.
• W2077690129 hasRelatedWork W1592770056 @default.
• W2077690129 hasRelatedWork W1889309137 @default.
• W2077690129 hasRelatedWork W2019412418 @default.
• W2077690129 hasRelatedWork W2020144632 @default.
• W2077690129 hasRelatedWork W2021446211 @default.

• next