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- W2077690841 abstract "Abstract Nafamstat mesilate (FUT-175), a new anticoagulant with a short half-life of biological activity, was used in five patients who had a history of bleeding during immunoadsorption using membrane plasmapheresis (IAP) due to excessive heparin. FUT-175 (1.2 mg/kg/h) was injected into the arterial blood line during IAP therapy. The prothrombin time (PT), activated partial thromboplastin time (APTT), bleeding time (BT), and complete blood count (CBC) were measured before and after IAP. The PT ( 17.7 ± 0.8 s) after IAP therapy was nearly 1.4 times the level of the PT (12.6 ± 0.6 s) before IAP treatment. The APTT levels after IAP (67.4 ± 2.8 s) were nearly 1.8 times the values before IAP (37.2 ± 2.3 s). There were no significant differences in red blood cell (RBC), hemoglobin (Hb) or platelet counts before and after IAP therapy. No patients developed thrombosis, hemorrhage, or other side effects during IAP. In conclusion, the optimal dosage of FUT-175 was 1.2 mg/kg body wt/h during immunoadsorption with membrane plasmapheresis (IAP). FUT-175 is recommended as a useful anticoagulant during IAP treatment of patients with an increased risk of bleeding." @default.
- W2077690841 created "2016-06-24" @default.
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- W2077690841 date "1993-07-01" @default.
- W2077690841 modified "2023-09-27" @default.
- W2077690841 title "Clinical assessment of Nafamstat mesilate (FUT-175): a new anticoagulant for immunoadsorption using membrane plasmapheresis (IAP)" @default.
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- W2077690841 doi "https://doi.org/10.1016/0955-3886(93)90014-l" @default.
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