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- W2077702049 abstract "Induction of diabetes in rats is associated with a significant elevation in the phenylalanine hydroxylating capacity of the liver. This phenomenon reflects an increase in the abundance of both phenylalanine hydroxylase protein and phenylalanine hydroxylase-specific mRNA. These changes can be abolished by insulin-dependent control of diabetes. We show here that the control of diabetes by oral administration of sodium orthovanadate will also nullify the diabetes-related alterations in phenylalanine hydroxylase expression. In addition, diabetes-induced changes in the extent of phosphorylation of phenylalanine hydroxylase are reversed by either insulin or vanadate treatment in vivo. These treatments also abolished the diabetes-related, approx. 30-fold, decrease in glucagon sensitivity of phenylalanine hydroxylation in isolated liver cells." @default.
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- W2077702049 date "1992-10-01" @default.
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- W2077702049 title "The effect of vanadate upon the expression of phenylalanine hydroxylase in streptozotoxin-diabetic rat liver" @default.
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- W2077702049 doi "https://doi.org/10.1016/0925-4439(92)90022-f" @default.
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