FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077706856> ?p ?o ?g. }

• W2077706856 endingPage "107" @default.
• W2077706856 startingPage "96" @default.
• W2077706856 abstract "Pharmacologic inhibitors of IκB kinase (IKK), especially IKK-β, have been developed to treat inflammatory diseases. However, their interactions with components of the NF-κB pathways are not fully known in allergic diseases. To examine whether IKK is involved in immediate hypersensitivity reactions and to determine whether counterregulatory mechanisms in the NF-κB activation system were active, we examined the role played by IKK components on mast cell degranulation using a murine ocular immediate hypersensitivity reaction model. Pharmacologic inhibition of IKK in mice caused paradoxical aggravation of the mast cell-mediated immediate hypersensitivity reaction and up-regulation in the expression of inflammatory cytokines. Downstream analyses showed that B-cell deficiency or treatment by IL-1 receptor antagonist corrected the aberrant activation of tissue-resident mast cells, which would indicate contribution by activated B cells. Analyses of co-cultures of tissue-resident mast cells showed the contribution of activated B cells to activation of mast cells and secretion of inflammatory cytokines. Aberrant activation of the NF-κB promoter in isolated B cells was induced exclusively by IKK-β inhibition and was negated by ablating IKK-α. Aggravated mast cell degranulation by pharmacologic IKK inhibition in the murine immediate hypersensitivity reaction was corrected by B-cell-targeted inhibition of IKK-α. Thus, IKK-β limits B-cell-mediated mast cell activation and inflammatory cytokine induction in immediate hypersensitivity by counterbalancing the activity of IKK-α." @default.
• W2077706856 created "2016-06-24" @default.
• W2077706856 creator A5003908771 @default.
• W2077706856 creator A5005018654 @default.
• W2077706856 creator A5019676153 @default.
• W2077706856 creator A5031522859 @default.
• W2077706856 creator A5037451883 @default.
• W2077706856 creator A5059972894 @default.
• W2077706856 creator A5072676682 @default.
• W2077706856 creator A5074846491 @default.
• W2077706856 creator A5080547934 @default.
• W2077706856 date "2013-07-01" @default.
• W2077706856 modified "2023-10-14" @default.
• W2077706856 title "Pharmacologic Inhibition of IκB Kinase Activates Immediate Hypersensitivity Reactions in Mice" @default.
• W2077706856 cites W1482145361 @default.
• W2077706856 cites W1515994079 @default.
• W2077706856 cites W1522366178 @default.
• W2077706856 cites W1531083195 @default.
• W2077706856 cites W1574666144 @default.
• W2077706856 cites W1657172089 @default.
• W2077706856 cites W1935708014 @default.
• W2077706856 cites W1966632253 @default.
• W2077706856 cites W1971591495 @default.
• W2077706856 cites W1971710973 @default.
• W2077706856 cites W1972538454 @default.
• W2077706856 cites W1976306629 @default.
• W2077706856 cites W1978019581 @default.
• W2077706856 cites W1982776595 @default.
• W2077706856 cites W1986781592 @default.
• W2077706856 cites W1992841021 @default.
• W2077706856 cites W1994485042 @default.
• W2077706856 cites W1999855196 @default.
• W2077706856 cites W2000111555 @default.
• W2077706856 cites W2003131704 @default.
• W2077706856 cites W2004857503 @default.
• W2077706856 cites W2017281018 @default.
• W2077706856 cites W2017987274 @default.
• W2077706856 cites W2026051427 @default.
• W2077706856 cites W2031163855 @default.
• W2077706856 cites W2033018194 @default.
• W2077706856 cites W2038687603 @default.
• W2077706856 cites W2041607290 @default.
• W2077706856 cites W2043687642 @default.
• W2077706856 cites W2047286951 @default.
• W2077706856 cites W2050130095 @default.
• W2077706856 cites W2059419250 @default.
• W2077706856 cites W2063830181 @default.
• W2077706856 cites W2067117198 @default.
• W2077706856 cites W2070413937 @default.
• W2077706856 cites W2072840117 @default.
• W2077706856 cites W2078813277 @default.
• W2077706856 cites W2098874403 @default.
• W2077706856 cites W2103690233 @default.
• W2077706856 cites W2113407881 @default.
• W2077706856 cites W2129483753 @default.
• W2077706856 cites W2138064370 @default.
• W2077706856 cites W2146561795 @default.
• W2077706856 cites W2154440027 @default.
• W2077706856 cites W2164944997 @default.
• W2077706856 cites W2171726169 @default.
• W2077706856 cites W2316580498 @default.
• W2077706856 cites W95988660 @default.
• W2077706856 doi "https://doi.org/10.1016/j.ajpath.2013.04.006" @default.
• W2077706856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23665348" @default.
• W2077706856 hasPublicationYear "2013" @default.
• W2077706856 type Work @default.
• W2077706856 sameAs 2077706856 @default.
• W2077706856 citedByCount "2" @default.
• W2077706856 countsByYear W20777068562015 @default.
• W2077706856 countsByYear W20777068562018 @default.
• W2077706856 crossrefType "journal-article" @default.
• W2077706856 hasAuthorship W2077706856A5003908771 @default.
• W2077706856 hasAuthorship W2077706856A5005018654 @default.
• W2077706856 hasAuthorship W2077706856A5019676153 @default.
• W2077706856 hasAuthorship W2077706856A5031522859 @default.
• W2077706856 hasAuthorship W2077706856A5037451883 @default.
• W2077706856 hasAuthorship W2077706856A5059972894 @default.
• W2077706856 hasAuthorship W2077706856A5072676682 @default.
• W2077706856 hasAuthorship W2077706856A5074846491 @default.
• W2077706856 hasAuthorship W2077706856A5080547934 @default.
• W2077706856 hasConcept C100175707 @default.
• W2077706856 hasConcept C126322002 @default.
• W2077706856 hasConcept C170493617 @default.
• W2077706856 hasConcept C184235292 @default.
• W2077706856 hasConcept C203014093 @default.
• W2077706856 hasConcept C2776914184 @default.
• W2077706856 hasConcept C2777730290 @default.
• W2077706856 hasConcept C2778690821 @default.
• W2077706856 hasConcept C2779726688 @default.
• W2077706856 hasConcept C49802076 @default.
• W2077706856 hasConcept C71924100 @default.
• W2077706856 hasConcept C86803240 @default.
• W2077706856 hasConcept C95444343 @default.
• W2077706856 hasConcept C98274493 @default.
• W2077706856 hasConceptScore W2077706856C100175707 @default.
• W2077706856 hasConceptScore W2077706856C126322002 @default.
• W2077706856 hasConceptScore W2077706856C170493617 @default.
• W2077706856 hasConceptScore W2077706856C184235292 @default.

• next