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• W2077708476 abstract "Study objective To evaluate a newly developed laser monitor in the measurement of positive end-expiratory pressure (PEEP)-induced changes in end-expiratory lung volume (EELV) in spontaneously breathing subjects. Design An open comparison between two different methods to assess breathing parameters. Setting A respiratory research unit. Participants Six spontaneously breathing, healthy volunteers. Interventions Stepwise increases of PEEP from 0 to 0.8 to 1.6 kPa during spontaneous breathing; repeated validation of the laser monitor in each subject. Measurements and results Pressure and flow were recorded at the airway opening. Abdominal wall displacement (AWD) measured by the laser sensor was recorded simultaneously. The time lag between the volume and the laser signals during baseline was 0.068±0.052 s and during maximal PEEP, 0.108±0.093 s. There was no baseline drift in either the PEEP or the AWD signals. Mean EELV decreased by 290 mL to 1,157 mL after the PEEP valve was removed. Within each individual, the ratio between EELV and AWD showed only small variations. Measurements of tidal volume (VT) and AWD showed good agreement at all PEEP levels. Mean VT decreased in all but one subject during PEEP. With the increase in PEEP, the end-expiratory abdominal baseline increased linearly over a large range of end-expiratory pressures with a flattening of the curve at high PEEP levels in all subjects. Conclusions The laser monitor is sufficiently accurate for measuring PEEP-induced changes in EELV during spontaneous breathing in healthy adult subjects. Monitors incorporating multiple laser sensors may have considerable clinical promise. To evaluate a newly developed laser monitor in the measurement of positive end-expiratory pressure (PEEP)-induced changes in end-expiratory lung volume (EELV) in spontaneously breathing subjects. An open comparison between two different methods to assess breathing parameters. A respiratory research unit. Six spontaneously breathing, healthy volunteers. Stepwise increases of PEEP from 0 to 0.8 to 1.6 kPa during spontaneous breathing; repeated validation of the laser monitor in each subject. Pressure and flow were recorded at the airway opening. Abdominal wall displacement (AWD) measured by the laser sensor was recorded simultaneously. The time lag between the volume and the laser signals during baseline was 0.068±0.052 s and during maximal PEEP, 0.108±0.093 s. There was no baseline drift in either the PEEP or the AWD signals. Mean EELV decreased by 290 mL to 1,157 mL after the PEEP valve was removed. Within each individual, the ratio between EELV and AWD showed only small variations. Measurements of tidal volume (VT) and AWD showed good agreement at all PEEP levels. Mean VT decreased in all but one subject during PEEP. With the increase in PEEP, the end-expiratory abdominal baseline increased linearly over a large range of end-expiratory pressures with a flattening of the curve at high PEEP levels in all subjects. The laser monitor is sufficiently accurate for measuring PEEP-induced changes in EELV during spontaneous breathing in healthy adult subjects. Monitors incorporating multiple laser sensors may have considerable clinical promise." @default.
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• W2077708476 date "1997-07-01" @default.
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• W2077708476 title "Measurements of PEEP-Induced Changes in Lung Volume" @default.
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• W2077708476 doi "https://doi.org/10.1378/chest.112.1.107" @default.
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