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- W2077715615 abstract "Marine biotoxins can accumulate in fish and shellfish, representing a possible threat for consumers. Many marine biotoxins affect neuronal function essentially through their interaction with ion channels or receptors, leading to different symptoms including paralysis and even death. The detection of marine biotoxins in seafood products is therefore a priority. Official methods for control are often still using in vivo assays, such as the mouse bioassay. This test is considered unethical and the development of alternative assays is urgently required. Chemical analyses as well as in vitro assays have been developed to detect marine biotoxins in seafood. However, most of the current in vitro alternatives to animal testing present disadvantages: low throughput and lack of sensitivity resulting in a high number of false‐negative results. Thus, there is an urgent need for the development of new in vitro tests that would allow the detection of marine biotoxins in seafood products at a low cost, with high throughput combined with high sensitivity, reproducibility, and predictivity. Mode of action based in vitro bioassays may provide tools that fulfil these requirements. This review covers the current state of the art of such mode of action based alternative assays to detect neurotoxic marine biotoxins in seafood." @default.
- W2077715615 created "2016-06-24" @default.
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- W2077715615 date "2013-12-05" @default.
- W2077715615 modified "2023-10-17" @default.
- W2077715615 title "Marine neurotoxins: State of the art, bottlenecks, and perspectives for mode of action based methods of detection in seafood" @default.
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- W2077715615 doi "https://doi.org/10.1002/mnfr.201300520" @default.
- W2077715615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24311541" @default.
- W2077715615 hasPublicationYear "2013" @default.
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