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- W2077716622 abstract "A new form of acetylcholinesterase insensitive to organophosphorus inhibitors was identified in house flies collected from animal farms in the U.K. Its degree of insensitivity to a number of inhibitors ranged from 4-fold (omethoate) to >40-fold (tetrachlorvinphos and dichlorvos) compared with our standard susceptible enzyme, and its spectrum of response to inhibitors differed widely from that of a previously studied insensitive form. In addition, the form of acetylcholinesterase reported here is unusual in having a 3.4-fold greater affinity (lower Km) for acetylthiocholine than the normal enzyme. The possible toxicological significance of this is discussed." @default.
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- W2077716622 date "1984-06-01" @default.
- W2077716622 modified "2023-10-18" @default.
- W2077716622 title "Different forms of insensitive acetylcholinesterase in insecticide-resistant house flies (Musca domestica)" @default.
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- W2077716622 doi "https://doi.org/10.1016/0048-3575(84)90101-9" @default.
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