FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077717401> ?p ?o ?g. }

• W2077717401 endingPage "236" @default.
• W2077717401 startingPage "228" @default.
• W2077717401 abstract "Haemostatic treatment modalities alternative to platelet transfusion are desirable to control serious acute bleeds in primary immune thrombocytopenia (ITP). This study challenged the hypothesis that recombinant activated factor VII (rFVIIa) combined with fibrinogen concentrate may correct whole blood (WB) clot formation in ITP. Blood from ITP patients (n = 12) was drawn into tubes containing 3·2% citrate and corn trypsin inhibitor 18·3 μg/ml. WB [mean platelet count 22 × 10(9) /l (range 0-42)] was spiked in vitro with buffer, donor platelets (+40 × 10(9) /l), rFVIIa (1 or 4 μg/ml), fibrinogen (1 or 3 mg/ml), or combinations of rFVIIa and fibrinogen. Coagulation profiles were recorded by tissue factor (0·03 pmol/l) activated thromboelastometry. Coagulation in ITP was characterized by a prolonged clotting time (CT, 1490 s (mean)) and a low maximum velocity (MaxVel, 3·4 mm × 100/s) and maximum clot firmness (MCF, 38·2 mm). Fibrinogen showed no haemostatic effect, whereas rFVIIa reduced the CT and increased the MaxVel. The combination of fibrinogen and rFVIIa revealed a significant synergistic effect, improving all parameters (CT 794 s, MaxVel 7·9 mm × 100/s, MCF 50·7 mm) even at very low platelet counts. These data suggest that rFVIIa combined with fibrinogen corrects the coagulopathy of ITP even at very low platelet counts, and may represent an alternative to platelet transfusion." @default.
• W2077717401 created "2016-06-24" @default.
• W2077717401 creator A5000071510 @default.
• W2077717401 creator A5028061272 @default.
• W2077717401 creator A5032700341 @default.
• W2077717401 creator A5066208623 @default.
• W2077717401 creator A5075239871 @default.
• W2077717401 date "2012-11-15" @default.
• W2077717401 modified "2023-10-05" @default.
• W2077717401 title "Combination of recombinant factor VIIa and fibrinogen corrects clot formation in primary immune thrombocytopenia at very low platelet counts" @default.
• W2077717401 cites W1566935349 @default.
• W2077717401 cites W187459506 @default.
• W2077717401 cites W1977689290 @default.
• W2077717401 cites W1981783866 @default.
• W2077717401 cites W1985940575 @default.
• W2077717401 cites W1986085903 @default.
• W2077717401 cites W1986408740 @default.
• W2077717401 cites W1991130709 @default.
• W2077717401 cites W1991617987 @default.
• W2077717401 cites W1995470175 @default.
• W2077717401 cites W2021263507 @default.
• W2077717401 cites W2022430958 @default.
• W2077717401 cites W2023160027 @default.
• W2077717401 cites W2031320632 @default.
• W2077717401 cites W2037652834 @default.
• W2077717401 cites W2043677343 @default.
• W2077717401 cites W2044646102 @default.
• W2077717401 cites W2046936517 @default.
• W2077717401 cites W2049766154 @default.
• W2077717401 cites W2054656237 @default.
• W2077717401 cites W2059190713 @default.
• W2077717401 cites W2068086215 @default.
• W2077717401 cites W2069062451 @default.
• W2077717401 cites W2075429091 @default.
• W2077717401 cites W2078132464 @default.
• W2077717401 cites W2085599612 @default.
• W2077717401 cites W2085814092 @default.
• W2077717401 cites W2113275609 @default.
• W2077717401 cites W2119446923 @default.
• W2077717401 cites W2119768870 @default.
• W2077717401 cites W2138507615 @default.
• W2077717401 cites W2151570815 @default.
• W2077717401 cites W2152282853 @default.
• W2077717401 cites W2168578759 @default.
• W2077717401 cites W75704903 @default.
• W2077717401 doi "https://doi.org/10.1111/bjh.12118" @default.
• W2077717401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23151086" @default.
• W2077717401 hasPublicationYear "2012" @default.
• W2077717401 type Work @default.
• W2077717401 sameAs 2077717401 @default.
• W2077717401 citedByCount "12" @default.
• W2077717401 countsByYear W20777174012013 @default.
• W2077717401 countsByYear W20777174012014 @default.
• W2077717401 countsByYear W20777174012016 @default.
• W2077717401 countsByYear W20777174012017 @default.
• W2077717401 countsByYear W20777174012018 @default.
• W2077717401 countsByYear W20777174012019 @default.
• W2077717401 countsByYear W20777174012020 @default.
• W2077717401 crossrefType "journal-article" @default.
• W2077717401 hasAuthorship W2077717401A5000071510 @default.
• W2077717401 hasAuthorship W2077717401A5028061272 @default.
• W2077717401 hasAuthorship W2077717401A5032700341 @default.
• W2077717401 hasAuthorship W2077717401A5066208623 @default.
• W2077717401 hasAuthorship W2077717401A5075239871 @default.
• W2077717401 hasBestOaLocation W20777174011 @default.
• W2077717401 hasConcept C126322002 @default.
• W2077717401 hasConcept C141071460 @default.
• W2077717401 hasConcept C1621761 @default.
• W2077717401 hasConcept C203014093 @default.
• W2077717401 hasConcept C26809991 @default.
• W2077717401 hasConcept C2777396833 @default.
• W2077717401 hasConcept C2777664302 @default.
• W2077717401 hasConcept C2778382381 @default.
• W2077717401 hasConcept C2778961111 @default.
• W2077717401 hasConcept C2779036427 @default.
• W2077717401 hasConcept C2779936836 @default.
• W2077717401 hasConcept C71924100 @default.
• W2077717401 hasConcept C77171857 @default.
• W2077717401 hasConcept C89560881 @default.
• W2077717401 hasConceptScore W2077717401C126322002 @default.
• W2077717401 hasConceptScore W2077717401C141071460 @default.
• W2077717401 hasConceptScore W2077717401C1621761 @default.
• W2077717401 hasConceptScore W2077717401C203014093 @default.
• W2077717401 hasConceptScore W2077717401C26809991 @default.
• W2077717401 hasConceptScore W2077717401C2777396833 @default.
• W2077717401 hasConceptScore W2077717401C2777664302 @default.
• W2077717401 hasConceptScore W2077717401C2778382381 @default.
• W2077717401 hasConceptScore W2077717401C2778961111 @default.
• W2077717401 hasConceptScore W2077717401C2779036427 @default.
• W2077717401 hasConceptScore W2077717401C2779936836 @default.
• W2077717401 hasConceptScore W2077717401C71924100 @default.
• W2077717401 hasConceptScore W2077717401C77171857 @default.
• W2077717401 hasConceptScore W2077717401C89560881 @default.
• W2077717401 hasIssue "2" @default.
• W2077717401 hasLocation W20777174011 @default.
• W2077717401 hasLocation W20777174012 @default.
• W2077717401 hasOpenAccess W2077717401 @default.
• W2077717401 hasPrimaryLocation W20777174011 @default.

• next