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• W2077731323 startingPage "41" @default.
• W2077731323 abstract "The selective CRF1 (corticotropin releasing factor type 1) receptor antagonist SSR125543 has been previously shown to attenuate the long-term behavioral and electrophysiological effects produced by traumatic stress exposure in mice. Sleep disturbances are one of the most commonly reported symptoms by people with post-traumatic stress disorder (PTSD). The present study aims at investigating whether SSR125543 (10 mg/kg/day/i.p. for 2 weeks) is able to attenuate sleep/wakefulness impairment induced by traumatic stress exposure in a model of PTSD in mice using electroencephalographic (EEG) analysis. Effects of SSR125543 were compared to those of the 5-HT reuptake inhibitor, paroxetine (10 mg/kg/day/i.p.), and the partial N-methyl-d-aspartate (NMDA) receptor agonist, d-cycloserine (10 mg/kg/day/i.p.), two compounds which have demonstrated clinical efficacy against PTSD. Baseline EEG recording was performed in the home cage for 6 h prior to the application of two electric foot-shocks of 1.5 mA. Drugs were administered from day 1 post-stress to the day preceding the second EEG recording session, performed 14 days later. Results showed that at day 14 post-stress, shocked mice displayed sleep fragmentation as shown by an increase in the occurrence of both non-rapid eye movement (NREM) sleep and wakefulness bouts. The duration of wakefulness, NREM and REM sleep were not significantly affected. The stress-induced effects were prevented by repeated administration of SSR125543, paroxetine and d-cycloserine. These findings confirm further that the CRF1 receptor antagonist SSR125543 is able to attenuate the deleterious effects of traumatic stress exposure." @default.
• W2077731323 created "2016-06-24" @default.
• W2077731323 creator A5001950169 @default.
• W2077731323 creator A5038701086 @default.
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• W2077731323 date "2015-02-01" @default.
• W2077731323 modified "2023-09-26" @default.
• W2077731323 title "The CRF1 receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: Comparison with paroxetine and d-cycloserine" @default.
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• W2077731323 doi "https://doi.org/10.1016/j.bbr.2014.11.006" @default.
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• W2077731323 hasPublicationYear "2015" @default.
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