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• W2077731650 abstract "Purpose: To investigate factors determining the presence of bilateral interictal epileptiform discharges (IEDs) in temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (HS).Methods: We analysed data of 243 TLE patients with unilateral HS who had long-term video-EEG. Eighty-one patients (33%) had bitemporal IEDs.Results: We categorised patients into a unilateral group (UG), a bilateral group (BG) according to presence of bitemporal IEDs. We found no difference between UG and BG regarding epilepsy duration, secondarily generalised seizures, and history of febrile seizures. Mean seizure frequency was significantly higher in the BG (UG: 7.7±14.7 seizures/month; BG: 13±35 seizures/month, P=0.01). We found a significant correlation between late epilepsy onset and the presence of bitemporal IEDs. The mean age at epilepsy onset in UG was 10.1±7.9 years, while in BG it was 13±9.2 years (P=0.02).Conclusions: The traditional concept of the evolution of mirror focus cannot apply for humans because the duration of epilepsy does not influence the evolution of bitemporal IEDs. Other factors, i.e. age at onset and seizure frequency may play a role in this process. The association between the higher seizure frequency and mirror foci indicates that the development of mirror focus depends on seizures and not on a progressive ‘interictal’ epileptogenesis." @default.
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• W2077731650 date "2003-12-01" @default.
• W2077731650 modified "2023-10-18" @default.
• W2077731650 title "Clinical differences in patients with unilateral hippocampal sclerosis and unitemporal or bitemporal epileptiform discharges" @default.
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• W2077731650 doi "https://doi.org/10.1016/s1059-1311(03)00069-4" @default.
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