FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077731916> ?p ?o ?g. }

• W2077731916 endingPage "12351" @default.
• W2077731916 startingPage "12346" @default.
• W2077731916 abstract "Yeast phosphatidylinositol transfer protein (Sec14p) function is essential for production of Golgi-derived secretory vesicles, and this requirement is bypassed by mutations in at least seven genes. Analyses of such 'bypass Sec14p' mutants suggest that Sec14p acts to maintain an essential Golgi membrane diacylglycerol (DAG) pool that somehow acts to promote Golgi secretory function. SPO14 encodes the sole yeast phosphatidylinositol-4,5-bisphosphate-activated phospholipase D (PLD). PLD function, while essential for meiosis, is dispensable for vegetative growth. Herein, we report specific physiological circumstances under which an unanticipated requirement for PLD activity in yeast vegetative Golgi secretory function is revealed. This PLD involvement is essential in 'bypass Sec14p' mutants where normally Sec14p-dependent Golgi secretory reactions are occurring in a Sec14p-independent manner. PLD catalytic activity is necessary but not sufficient for 'bypass Sec14p', and yeast operating under 'bypass Sec14p' conditions are ethanol-sensitive. These data suggest that PLD supports 'bypass Sec14p' by generating a phosphatidic acid pool that is somehow utilized in supporting yeast Golgi secretory function." @default.
• W2077731916 created "2016-06-24" @default.
• W2077731916 creator A5001377302 @default.
• W2077731916 creator A5022522725 @default.
• W2077731916 creator A5022702564 @default.
• W2077731916 creator A5045975673 @default.
• W2077731916 creator A5053295916 @default.
• W2077731916 creator A5055373586 @default.
• W2077731916 creator A5064147794 @default.
• W2077731916 date "1998-10-13" @default.
• W2077731916 modified "2023-09-27" @default.
• W2077731916 title "Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects" @default.
• W2077731916 cites W1537782690 @default.
• W2077731916 cites W1908999526 @default.
• W2077731916 cites W1930246657 @default.
• W2077731916 cites W1965441259 @default.
• W2077731916 cites W1965658458 @default.
• W2077731916 cites W1970666556 @default.
• W2077731916 cites W1973593487 @default.
• W2077731916 cites W1973624256 @default.
• W2077731916 cites W1973782344 @default.
• W2077731916 cites W1976302801 @default.
• W2077731916 cites W1977649493 @default.
• W2077731916 cites W1978936325 @default.
• W2077731916 cites W1979945257 @default.
• W2077731916 cites W1982304503 @default.
• W2077731916 cites W1986267127 @default.
• W2077731916 cites W2002341882 @default.
• W2077731916 cites W2003123776 @default.
• W2077731916 cites W2005445415 @default.
• W2077731916 cites W2022013116 @default.
• W2077731916 cites W2040589276 @default.
• W2077731916 cites W2049144892 @default.
• W2077731916 cites W2051285749 @default.
• W2077731916 cites W2059637730 @default.
• W2077731916 cites W2059775037 @default.
• W2077731916 cites W2059906052 @default.
• W2077731916 cites W2067776100 @default.
• W2077731916 cites W2093160716 @default.
• W2077731916 cites W2096005517 @default.
• W2077731916 cites W2096716792 @default.
• W2077731916 cites W2104302589 @default.
• W2077731916 cites W2139868649 @default.
• W2077731916 cites W2145120474 @default.
• W2077731916 cites W2154430600 @default.
• W2077731916 cites W331717834 @default.
• W2077731916 cites W4210964849 @default.
• W2077731916 doi "https://doi.org/10.1073/pnas.95.21.12346" @default.
• W2077731916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22834" @default.
• W2077731916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9770489" @default.
• W2077731916 hasPublicationYear "1998" @default.
• W2077731916 type Work @default.
• W2077731916 sameAs 2077731916 @default.
• W2077731916 citedByCount "150" @default.
• W2077731916 countsByYear W20777319162012 @default.
• W2077731916 countsByYear W20777319162013 @default.
• W2077731916 countsByYear W20777319162014 @default.
• W2077731916 countsByYear W20777319162016 @default.
• W2077731916 countsByYear W20777319162017 @default.
• W2077731916 countsByYear W20777319162018 @default.
• W2077731916 countsByYear W20777319162019 @default.
• W2077731916 countsByYear W20777319162020 @default.
• W2077731916 countsByYear W20777319162021 @default.
• W2077731916 countsByYear W20777319162022 @default.
• W2077731916 crossrefType "journal-article" @default.
• W2077731916 hasAuthorship W2077731916A5001377302 @default.
• W2077731916 hasAuthorship W2077731916A5022522725 @default.
• W2077731916 hasAuthorship W2077731916A5022702564 @default.
• W2077731916 hasAuthorship W2077731916A5045975673 @default.
• W2077731916 hasAuthorship W2077731916A5053295916 @default.
• W2077731916 hasAuthorship W2077731916A5055373586 @default.
• W2077731916 hasAuthorship W2077731916A5064147794 @default.
• W2077731916 hasBestOaLocation W20777319161 @default.
• W2077731916 hasConcept C104317684 @default.
• W2077731916 hasConcept C119062480 @default.
• W2077731916 hasConcept C12927208 @default.
• W2077731916 hasConcept C14036430 @default.
• W2077731916 hasConcept C143065580 @default.
• W2077731916 hasConcept C158617107 @default.
• W2077731916 hasConcept C181199279 @default.
• W2077731916 hasConcept C195794163 @default.
• W2077731916 hasConcept C2776909261 @default.
• W2077731916 hasConcept C2778918659 @default.
• W2077731916 hasConcept C2779222958 @default.
• W2077731916 hasConcept C36020004 @default.
• W2077731916 hasConcept C41625074 @default.
• W2077731916 hasConcept C55493867 @default.
• W2077731916 hasConcept C6182249 @default.
• W2077731916 hasConcept C62478195 @default.
• W2077731916 hasConcept C6492254 @default.
• W2077731916 hasConcept C86803240 @default.
• W2077731916 hasConcept C95444343 @default.
• W2077731916 hasConceptScore W2077731916C104317684 @default.
• W2077731916 hasConceptScore W2077731916C119062480 @default.
• W2077731916 hasConceptScore W2077731916C12927208 @default.
• W2077731916 hasConceptScore W2077731916C14036430 @default.
• W2077731916 hasConceptScore W2077731916C143065580 @default.
• W2077731916 hasConceptScore W2077731916C158617107 @default.

• next